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ProteomicsA novel blood brain barrier-permeable IRE1 inhibitor prevents Glioblastoma relapse in mice
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional serine/threonine kinase and endoribonuclease that is a major mediator of the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse environmental cues such as hypoxia or nutrient s...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD026908 | Pride
Ire1 Glioblastoma Unfolded protein response Inhibitors Endoplasmic reticulum 
ProteomicsMetalloprotease-mediated cleavage of CD95 Ligand: QTOF Xevo XS data
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non-apoptotic signals. CD95L can exist as ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD039211 | Pride
Cd95l Metalloprotease Proteolytic cleavage 
ProteomicsReflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
In the past decades many studies reported the presence of Endoplasmic Reticulum (ER) resident proteins in the cytosol. However the mechanisms by which these proteins relocate and whether they exert cytosolic functions remain unknown. We found that select ER luminal proteins accumulate in the cytosol...
ORGANISM(S): Homo sapiens (Human) 
2021-05-03 | PXD023567 | Pride
Tumor cells Upr Endoplasmic reticulum 
ProteomicsA conserved AAA+ ATPase network regulates endoplasmic reticulum stress-induced transcription
In C. elegans cdc-48.2(-/-) mutant animals, ER stress-mediated expression of the UPR ckb-2::GFP reporter transgene is abolished. Here, we have used this phenotype in a genome-wide RNAi screen to identify genes involved in the CDC-48.2 mediated ER stress transcription. Combined with a comparative pro...
ORGANISM(S): Caenorhabditis elegans 
2015-09-30 | PXD000636 | Pride
Proteomic screen C. elegans Reptin Cdc-48 Rnai screen Vcp Endoplasmic reticulum stress P97 Ruvb-2 
ProteomicsStress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
Endoplasmic Reticulum (ER) stress is a hallmark of various diseases, which is dealt with through the activation of an adaptive signaling pathway named the Unfolded Protein Response (UPR). This response is mediated by three ER-resident sensors and the most evolutionary conserved, IRE1α signals throug...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-02-21 | PXD023433 | Pride
Upr Xbp1s Endoplasmic reticulum 
ProteomicsiTRAQ proteomics of non fibrotic carcinoma on Human Liver
We present a study of hepatocellular carcinoma developed on non-fibrotic liver (nfHCC) that combines complementary quantitative iTRAQ-based proteomics and phosphoproteomics approaches. Using both approaches, we analyzed a set of 24 samples (18 nfHCC vs 6 non-tumor liver tissue).
ORGANISM(S): Homo sapiens (Human) 
2014-09-18 | PXD001253 | Pride
Human Itraq Non fibrotic hepatocellular carcinoma 
TranscriptomicsGene profiling: U87 IRE1 dominant negative cells vs. U87ctrl cells in culture
Transcriptome analysis was performed from human U87 glioblastoma cell clones: U87 IRE1.NCK DN (U87dn, IRE1 dominant negative) and U87 control (U87ctrl, empty plasmid). Cells were grown in DMEM supplemented with 10% FBS and glutamine for 16 hours in culture prior mRNA isolation and analyses U87dn c...
ORGANISM(S): Homo sapiens 
2010-08-08 | E-GEOD-22385 | biostudies-arrayexpress
ProteomicsThe human IRE1 in situ proximal signalosome
The unfolded protein response (UPR) is a key adaptive pathway that controls endoplasmic reticulum (ER) homeostasis. The UPR is transduced by three ER-resident proteins acting as sensors of ER homeostasis in the lumen of this compartment and triggering select downstream signaling pathways in the cyto...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD051657 | Pride
Human Ire1 Upr Bioid 
TranscriptomicsDual IRE1 RNase functions dictate glioblastoma development
The transcriptome dataset has been used to validate on a GBM patient cohort (n=117) the IRE1-dependent gene expression signature identified in U87 cell line.
ORGANISM(S): Homo sapiens 
2018-01-09 | E-MTAB-6326 | biostudies-arrayexpress
ProteomicsER-stress-induced_transcription
A conserved AAA+ ATPase network regulates ER-stress-induced transcription
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2015-12-31 | PAe005594 | PeptideAtlas
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