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ProteomicsDatabase search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes
Unconventional epitopes presented by HLA class I complexes are emerging targets for T cell targeted immunotherapies. Their identification by mass spectrometry required development of novel methods to cope with the large number of theoretical candidates. Methods to identify post-translationally splic...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD031709 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsSPI-ART and the features of cis-spliced peptides in HLA class I immunopeptidomes
The identification of peptides presented by HLA class I molecules to CD8+ T cells – i.e. the HLA-I immunopeptidome - is a useful tool to fish epitopes suitable for vaccinations and immunotherapies against cancer, infection and autoimmunity. These peptides are mainly generated by proteasomes through ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025346 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstrat...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD017922 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstra...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD009660 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
UnknownDatabase search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes.
Not available
S-EPMC9286349 | biostudies-literature
UnknownProteasome-Generated <i>cis</i>-Spliced Peptides and Their Potential Role in CD8<sup>+</sup> T Cell Tolerance.
Not available
S-EPMC7943738 | biostudies-literature
UnknownPotential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and <i>cis</i>-Spliced <i>Zwitter</i> Epitope Candidates in Type 1 Diabetes.
Not available
S-EPMC8082463 | biostudies-literature
ProteomicsDigging deeper into the HLA peptidome – Characterization of the post-translationally modified peptides
Peptides displayed by MHC molecules on a cell’s surface, referred to as its immunopeptidome, play an important role in the adaptive the immune response. Antigen processing for MHC class I presentation is a ubiquitous pathway present in all nucleated cells which generate and present peptides of both ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD024562 | Pride
Spliced peptides Immunopeptidome Post-translational modifications Mhc class i Mhc binding motifs 
UnknownInvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides.
Not available
S-EPMC9832164 | biostudies-literature
ProteomicsElucidation of the signatures of proteasome-catalysed peptide splicing
Proteasomes catalyse the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role for proteasome-catalysed peptide splicing (PC...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD021339 | Pride
Protein splicing Proteasome Splicing mechanism 
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