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UnknownPostoperative outcomes after preoperative ustekinumab exposure in patients with Crohn's disease: a systematic review and meta-analysis.
Not available
S-EPMC8375651 | biostudies-literature
ProteomicsHepG2 GalNAc-T1/2 Bump-and-hole secretome glycopeptide data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAC analog into the secretome of HepG2 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-azide. Glycoproteins were...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018048 | Pride
Human Bioorthogonal Galnac-t Liver Glycopeptide Click Secretome Hepg2 
ProteomicsK-562 GalNAc-T1/2 Bump-and-hole Whole cell lysate proteomics data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAc analog into the glycoproteins on the cell surface of K-562 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-a...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017989 | Pride
Human Mucin Bioorthogonal Galnac-t Click Glycoprotein K-562 
TranscriptomicsChromatin immunoprecipitation of human HNF3b and E2F4, and mouse NeuroD1, for THEME analysis
Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover sequence patterns in the bound regions that may be recognized by the immunoprecipitated protein. However, the disco...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-8 | biostudies-arrayexpress
ProteomicsOgasawara et al_photo-stereoprobes
Chemical proteomics enables the global assessment of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery. The range of small molecules explored by chemical proteomics has, however, been limited. Here, we describe a diversity-o...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD050096 | Pride
Proteomics Diazirine Chemical biology Photo-reactive probe Phenotypic screening 
ProteomicsProteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors
Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (‘stereoprobes’) offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the synthesis and chemical proteomic characterization of stereoprobes b...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD060339 | Pride
Lipid biology Chemical biology Chemical proteomics Electrophilic probes 
ProteomicsHepG2 secretome tagged with the sugar analogs GalNAz and GalNAzMe
Chemically modified analogs of GalNAc, termed GalNAz or GalNAzMe, were incorporated in secreted glycoproteins. The compounds contain bioorthogonal, clickable functional groups that allowed for enrichment using biotin. Chemical glycoproteomics was performed after on-bead digestion and cleavage of gly...
ORGANISM(S): Homo sapiens (Human) 
2020-09-14 | PXD020648 | Pride
Glycosylation Bioorthogonal Mucin Chemical proteomics Enrichment Biotin 
TranscriptomicsSinorhizobium meliloti 1021 delta divJ
Effect of deletion of DivJ kinase on the transcriptome of Sinorhizobium meliloti 1021.
ORGANISM(S): Sinorhizobium meliloti 
2013-07-29 | E-MEXP-3942 | biostudies-arrayexpress
ProteomicsSimple , Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes
Herein we describe a new enantioselective route for the synthesis of all stereoisomers of 2,3-disubstituted azetidines. This approach uses simple strain release functionalization of preformed 1-azabicyclobutanes (ABBs), which enables installation of a wide array of nucleophiles at the C3-position. C...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055926 | Pride
Chemical synthesis Proteomics Covalent probes Chemical biology 
ProteomicsPhagoID: Quantitative in situ proximity labeling defines the proteomes of bead- and microbe-containing phagosome lumina across species, maturation, and immune activation
The phagosome is an immune organelle that integrates signals from diverse cargos to drive pathogen killing, tissue homeostasis, and antigen presentation. How this compartment coordinates such diverse functions remains incompletely understood. A comprehensive view of phagosomal composition across cel...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-10-02 | PXD055598 | Pride
Apex2 Turboid Proximity labeling Phagosome proteome Phagosomal proteome Hrp Phagosome lumen Phagosomal lumen Phagosome 
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