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ProteomicsThe cross-linking mass spectrometry (CX-MS) results of Human TIP60 complex (hTIP60)
Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer exchange activities. It plays roles in diverse cellular processes including transcription, DNA repair, cell cycle control, and embryonic development. We performed structural study on human TIP60 complex with cryo...
ORGANISM(S): Homo sapiens (Human) 
2024-07-11 | PXD048625 | Pride
Human Tip60 Cx-ms 
ProteomicsMapping the protein-protein interaction interface between recombinant CB1R and GlyT2 using cross-linking mass spectrometry
This project aims to elucidate a novel molecular mechanism driving mechanical allodynia, a debilitating neuropathic pain condition. We focus on a spinal cord “allodynia gate” circuit in which nerve injury leads to disinhibition of protein kinase Cγ (PKCγ) excitatory neurons. Our findings reveal that...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070478 | Pride
Cb1r protein Cx-ms Glyt2 protein 
ProteomicsConfirmation of the binding site of spermine to ATP13A2 protein
To better understand human ATP13A2-mediated polyamine transport, we used single-particle cryo-electron microscopy to solve high-resolution structures of human ATP13A2. Interestingly, we found polyamine binding at multiple sites distributed along the transmembrane regions in ATP13A2 protein, which ha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037493 | Pride
Atp13a2 Cx-ms Spm 
ProteomicsLinX - software for evaluation of CX-MS data
Chemical cross-linking mass spectrometry data from analysis of N14/N15 labeled proteins
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-03-11 | PXD023522 | Pride
Linx Chemical cross-linking Mass spectrometry Ledg Foxo4 Nkrp1b 
ProteomicsCross-linking of the microtubule binding N-terminal domain of the companion of cellulose synthase 1 protein (CC1∆C223) from Arabidopsis thaliana with tubulin
In this study, we use Cross-linking Mass Spectrometry to identify the interaction sites of the microtubule binding N-terminal domain of the companion of cellulose synthase 1 protein (CC1∆C223) from Arabidopsis thaliana with tubulin. We consistently detected four cross-linked peptides of CC1∆C223 to ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-08 | PXD009260 | Pride
Arabidopsis thaliana Cx-ms Cross-linking Microtubule Tubulin 
ProteomicsChemical cross-linking of the Spindly-RZZ complex followed by mass spectrometry
Kinetochores are macromolecular assemblies that connect chromosomes to spindle microtubules during mitosis. The metazoan-specific ≈800 kilodalton ROD-Zwilch-ZW10 (RZZ) complex builds a fibrous corona that assembles on mitotic kinetochores prior to microtubule attachment to promote chromosome alignme...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD005287 | Pride
Human  spindly-rzz complex  spindly  rod  zwilch  zw10  cx-ms  orbitrap 
UnknownStructural studies of the human α1 glycine receptor via site-specific chemical cross-linking coupled with mass spectrometry.
Not available
S-EPMC11550363 | biostudies-literature
ProteomicsIntact extracellular vesicle cross-linking on vesicles derived from MDA-MB-231 and LM2 cells
The development of any pharmaceutical requires characterization of the compound, usually be several techniques. Therefore, characterizing the protein content and biochemical state of EVs is of great importance for their useif they are to be used as biopharmaceuticals. Structural characterization of ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD029591 | Pride
Tnbc Evs Xl-ms Structural proteomics Cx-ms 
ProteomicsTRIM72 cross-linked by the higher-order assembly on the negatively charged liposome surface
Plasma membrane repair is a rapid cellular response for resealing of membrane for cell survival. In the early step of repair process, TRIM72 is known to a key initiator for facilitating patch membrane to the damaged membrane site. When acute membrane injury happens, TRIM72 is also known to sensitive...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD024946 | Pride
Cx-ms Trim72 Lc-ms/ms 
UnknownProbing structures of large protein complexes using zero-length cross-linking.
Not available
S-EPMC4628899 | biostudies-literature
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