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UnknownWhole Blood Proteome Dynamics Defines Predictive Diagnostic and Prognostic Signatures of Cryptococcal Infection.
Not available
S-EPMC12664494 | biostudies-literature
ProteomicsTemporal proteome remodeling from whole blood defines predictive diagnostic and prognostic signatures of cryptococcal infection
Fungal diseases impact the lives of millions of people across the globe ranging from superficial to systemic infections. Treatment options toward fungal diseases are limited given the emergence of new pathogens with intrinsic resistance and heightened evolution toward resistant strains. To effective...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-25 | PXD064393 | Pride
Lc-ms Infectious disease Whole blood 
ProteomicsTemporal and thermal optimization of trypsin digestion for the cryptococcal proteome
Mass spectrometry-based proteomics supports investigation into diverse biological systems, providing insights into regulation, signaling, modifications, and interactions. Optimized sample preparation is critical to ensure robust and reproducible analyses balanced with time and cost. In this article,...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-10-12 | PXD056755 | Pride
Cryptococcus neoformans Total proteome Trypsin 
ProteomicsEffects of human immunoglobulins on Cryptococcus neoformans morphology and proteome
Cryptococcus neoformans (Cn) is the main cause of fungal meningitis (CM) in people living with HIV. Perturbations in levels of normal immunoglobulin (Ig) levels are observed in these individuals, but their association with CM pathogenesis is unclear. Here, we investigated the physical and biological...
ORGANISM(S): Cryptococcus neoformans 
2026-01-26 | PXD072710 | Pride
Igm Cryptococcal capsule Cryptococcus neoformans Human immunoglobulins Igg Hiv Cryptococcal proteome. And iga Glucuronoxylomannan 
ProteomicsCryptococcus neoformans proteins during fungal-macrophage interaction
Cryptococcus neoformans interactions with murine macrophages are critical for disease. In this project we analyzed fungal proteins which were co-purified with murine host proteins after interaction. H99 C. neoformans was opsonized with mAb 18B7 and addedd to murine macrophages. Then murine cells wer...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD024951 | Pride
Host-pathogen interactions Cryptococcus neoformans Fungi 
UnknownProteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, to influence fungal virulence determinants in cryptococcosis.
Not available
S-EPMC11302251 | biostudies-literature
ProteomicsCryptococcal infectome uncovers new therapeutic targets
Mortality and morbidity rates of invasive fungal infections are rising as new pathogens emerge, antifungal resistance rates rise, and susceptible populations increase in numbers. Innovative strategies to identify and characterize novel druggable targets and investigate mechanisms of action driving f...
ORGANISM(S): Mus musculus (Mouse) Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2026-05-20 | PXD051506 | Pride
Drug discovery Virulence Quantitative proteomics Immunization Fungal pathogenesis Infection Phenome 
ProteomicsCryptococcal infectome uncovers new therapeutic targets
Mortality and morbidity rates of invasive fungal infections are rising as new pathogens emerge, antifungal resistance rates rise, and susceptible populations increase in numbers. Innovative strategies to identify and characterize novel druggable targets and investigate mechanisms of action driving f...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2026-05-20 | PXD051675 | Pride
Virulence Fungal Infectome 
ProteomicsSchizophrenia Proteome Data High Resolution Method
PTM-tolerant quantitative proteome analysis of plasma collected from schizophrenia patients and nonspychiatric healthy controls.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-02 | MSV000086977 | MassIVE
ProteomicsDisruption of ClpX reverts fluconazole susceptibility for Cryptococcus neoformans through modified heme biosynthesis and ergosterol production
Fungal disease impacts the lives of almost a billion people across the globe. The opportunistic human fungal pathogen, Cryptococcus neoformans, causes cryptococcal meningitis in immunocompromised individuals with high fatality rates in response to limited treatment options. Moreover, the emergence o...
ORGANISM(S): Fungi Cryptococcus neoformans var. grubii 
2025-07-04 | PXD052366 | Pride
Clpx Cryptococcus neoformans Ergosterol Heme Antifungal resistance Quantitative proteomics Fluconazole 
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