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ProteomicsPhosphoproteomic analysis of bFGF ± C7/Prostetin in D425 cells
FGFR signaling is a potent driver of medulloblastoma (MB) progression, driving an invasive phenotype. We explored the impact of a short term bFGF stimulation in D425 MB cells on phosphoproteome level and studied the effect of pretreatment with the FRS2 targeting small molecule C7, or the MAP4K4 inhi...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD062602 | Pride
Cancer Pediatric Phosphoproteomics Map4k4 Cerebellum Brain cancer Fgfr Frs2 D425 Bfgf Medulloblastoma C7 Prostetin 
TranscriptomicsOTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation
The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. The role of OTX2 in medulloblastoma and its downstream targets are uncle...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22875 | biostudies-arrayexpress
GenomicsRNA sequencing analysis of intracranial D425 xenografts treated with ASO-CTRL and ASO-lnc-HLX 2-7
RNA sequencing analysis of intracranial D425 xenografts treated with ASO-CTRL and ASO-lnc-HLX 2-7
PRJNA780420 | ENA
TranscriptomicsRNA sequencing analysis of intracranial D425 xenografts treated with ASO-CTRL and ASO-lnc-HLX 2-7
To gain more insights into the functional significance of lnc-HLX-2-7, gene expression profiles were measured using D425 (sh-CTRL), D425 (sh-HLX) and intracranial D425 xenografts treated with ASO-CTRL and ASO-lnc-HLX 2-7 by RNA sequencing.
ORGANISM(S): Homo sapiens 
2023-11-01 | GSE188746 | GEO
GenomicsRNA sequencing analysis of stable medulloblastoma DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211
RNA sequencing analysis of stable medulloblastoma DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211
PRJNA780435 | ENA
TranscriptomicsRNA sequencing analysis of stable medulloblastoma DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211
To investigate the role of miR-211 in medulloblastoma, next-generation sequencing analysis of RNA extracted from DAOY, D425, and CHLA01 cells expressing vector only (V/O) or miR-211 were performed.
ORGANISM(S): Homo sapiens 
2023-11-01 | GSE188813 | GEO
TranscriptomicsRNA sequencing analysis of lnc-HLX-2-7 interacting genes and pathways in medulloblastoma
To gain more insights into the functional significance of lnc-HLX-2-7, gene expression profiles were measured using D425, D425 lnc-HLX-2-7 KD and their intracranial xenografts by RNA sequencing.
ORGANISM(S): Homo sapiens 
2020-10-30 | GSE151810 | GEO
TranscriptomicsSingle cell RNA sequencing analysis of lnc-HLX-2-7 knock out in medulloblastoma
To gain more insights into the functional significance of lnc-HLX-2-7, gene expression profiles were measured using D425, D425 lnc-HLX-2-7 KD and their intracranial xenografts by RNA sequencing. Dissociated tumor cells were used for gel bead emulsion (GEM) with chromium controler (10X genomics).
ORGANISM(S): Homo sapiens 
2020-10-30 | GSE156043 | GEO
TranscriptomicsMiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma
The expression of miR-592 was found to reduce the malignant potential of Group 3 medulloblastoma cell lines, D283, D425 and HD-MB03. RNA-seq analysis was carried out to identify genes differentially expressed upon miR-592 expression in the medulloblastoma cell lines. MiR-592 expression was found to ...
ORGANISM(S): Homo sapiens 
2021-08-26 | GSE147145 | GEO
UnknownPreclinical assessment of MAGMAS inhibitor as a potential therapy for pediatric medulloblastoma.
Not available
S-EPMC11495579 | biostudies-literature
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