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ProteomicsProteomic Epithelial-To-Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early-Onset Preeclampsia
Preeclampsia (PE), a hypertensive disorder in pregnancy, is linked to placental vascular remodelling, increasing risks of fetal growth restriction and long-term offspring health problems. The role of fetoplacental endothelial cell-derived extracellular vesicles (EVs) in PE remains underexplored. Thi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068733 | Pride
Proteomics Extracellular vesicles Lfq Preeclampsia 
ProteomicsComparative proteomics of paired human vocal fold and oral mucosa tissue
This dataset brief is about the descriptive proteomic comparison of human oral mucosa and vocal fold tissues by high-resolution mass spectrometry (CID-MS/MS). The vast majority of voice disorders is associated with changes of the unique but delicate tissue of the human vocal folds, wheras the abili...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD025519 | Pride
Oral mucosa Comparative proteomics Human tissue Vocal folds 
ProteomicsComparative proteomics of common allergenic tree pollens of birch, alder and hazelComparative proteomics of common allergenic tree pollens of birch, alder and hazel
It is known that, in addition to known allergens, other proteins in pollen can aid the development of an immune response in allergenic individuals. The contribution of the “unknown” protein allergens becomes especially prominent in phylogenetically related species where, despite of high homology of ...
ORGANISM(S): Alnus glutinosa Corylus avellana Betula pendula 
2021-04-21 | PXD021133 | Pride
Birch Alder Proteomics Pollen Hazel 
ProteomicsComparative Proteomics of PairedVocal Fold and Oral Mucosa Fibroblasts
Injuries of the vocal folds frequently heal with scar formation, which can have lifelong detrimental impact on voice quality. Current treatments to prevent or resolve scars of the vocal fold mucosa are highly unsatisfactory. In contrast, the adjacent oral mucosa is mostly resistant to scarring. Thes...
ORGANISM(S): Ovis aries 
2017-01-23 | PXD005106 | Pride
Lamina propria Oral mucosa Wound healing Fibrosis Laryngology Scar Vocal folds Fibroblasts 
ProteomicsProteomic analysis of vocal fold fibroblasts exposed to cigarette smoke extract
Reinke’s edema is a cigarette associated, benign, mostly bilateral lesion of the vocal folds leading to dysphonia and dyspnea. Until today information about pathophysiology is only scarce, treatment is only surgical. To explore the pathophysiology of Reinke’s edema, we exposed near primary human voc...
ORGANISM(S): Homo sapiens (Human) 
2019-08-06 | PXD010640 | Pride
Cigarette smoke extract Fibroblasts Proteomics 
ProteomicsRbp95 binds 25S rRNA helix H95 and cooperates with the Npa1 complex during early pre-60S particle maturation
Eukaryotic ribosome synthesis involves more than 200 assembly factors, which promote ribosomal RNA (rRNA) processing, modification and folding, and assembly of ribosomal proteins. The formation and maturation of the earliest pre-60S particles requires structural remodeling by the Npa1 complex, but i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-13 | PXD030106 | Pride
Ribosome assembly factor Yeast S. cerevisiae Tandem-affinity purification (tap) Npa1 Pre-60s particles Rbp95 
ProteomicsHDAC inhibition improves cardiopulmonary and mitochondrial function in a feline model with features of Heart Failure with Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFpEF) is a major global health problem but there are no effective therapies. The aim of this study was to assess the effects of histone deacetylase (HDAC) inhibition on cardiopulmonary structure, function, and metabolism in a large mammalian (feline) ...
ORGANISM(S): Felis catus (Cat) (Felis silvestris catus) 
2021-09-08 | PXD013663 | Pride
Myofibril relaxation Hypertrophy Cat Hdac Heart failure Acetylation proteomics Pulmonary hypertension Lung compliance 
ProteomicsProteome of ATGL knock-out A549 cells compared to A549 wild type cells
Comparison of ATGL-KO and ATGL-WT A549 cell proteomes
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD007223 | Pride
Human A549 Atgl Lc-ms/ms 
ProteomicsComplementary omics strategies to dissect p53 signaling networks under nutrient stress
Signaling trough cytoplasmic or nuclear action of p53 is a major response mechanism to cellular stresses. While p53 protein levels have been shown to increase upon nutrient stresses such as starvation, the exact signaling cascade in this context remains elusive. Here, we show in a human hepatoma cel...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD028341 | Pride
Response to starvation Human hepatoma cell line Rapid immunoprecipitation ms P53 
ProteomicsExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction
Aims and introduction: Cardiac fibrosis is the hallmark of cardiac disease, particularly myocardial infarction (MI), and is one of the most prevalent causes of heart failure. MI is intricately linked to inflammation, extracellular matrix (ECM) remodelling, and cardiac fibrosis, however the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027626 | Pride
Ecm1 Adult human cardiac fibroblast (hucfb) cell line Human Cardiac wound healing Extracellular matrix Heart failure (hf) 
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