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ProteomicsA 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in cancer
The remodeling of the extracellular matrix (ECM) by proteases releases fragments that promote tumor progression and metastasis. The protease cathepsin D (cath-D), a marker of poor prognosis in triple-negative breast cancer (TNBC), is aberrantly secreted in the ECM. Using degradomics, we discovered th...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022826 | Pride
Ecm Tnbc Protease Proteolysis Matricellular protein Tumor microenvironment 
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ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and fu...
... A Overmyer, F.-Nora Vogtle, Danielle C Lohman, Kathryn L Schueler, Alan D Attie, Chris Meisinger, Joshua J Coon, David J Pagliarini. (2018) “Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.” biorx: https://doi.org/10.1101/426247
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
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ProteomicsComparative proteomic analysis of hemolymph from uninfected and Candidatus Liberibacter asiaticus-infected Diaphorina citri
Hemolymph was characterized from Diaphorina citri adults infected with the phytopathogen, Candidatus Liberibacter asiaticus (CLas) and compared with that from uninfected psyllids. This study identified 5531 and 3220 peptides within infected and uninfected hemolymph using nano LC-MS/MS. A reduced numb...
ORGANISM(S): Candidatus Carsonella ruddii DC Wolbachia endosymbiont of Diaphorina citri Liberibacter endosymbiont of Diaphorina citri Diaphorina citri (Asian citrus psyllid) Candidatus Profftella armatura 
2017-01-18 | PXD005404 | Pride
Asian citrus psyllid Hemolymph Diaphorina citri Endosymbionts Hemiptera 
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ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics analy...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
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MetabolomicsGNPS-Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses
Paper Title: Passive accumulation of alkaloids in non-toxic frogs challenges paradigms of the origins of acquired chemical defenses. Author List; Rebecca D Tarvin, Jeffrey L Coleman, David A Donoso, Mileidy Betancourth-Cundar, Karem Lopez-Hervas, Kimberly S Gleason, J Ryan Sanders, Jacqueline M Smith, Sa...
ORGANISM(S): Multiple Frog Species 
MSV000095866 | GNPS
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Proteomics2019 Brecht et al. RAG1 vAbl BioID LC-MS/MS
To identify mechanisms that regulate V(D)J recombination, we used proximity-dependent biotin identification to analyze the interactomes of full length and truncated forms of RAG1 in pre-B cells. This revealed an association of RAG1 with numerous nucleolar proteins in a manner dependent on amino acids...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-02 | PXD016221 | Pride
Pre b cell Vabl cell V(d)j recombination Bioid Rag1 
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GenomicsWomen's Health Initiative Clinical Trial and Observational Study

The Women's Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. The original WHI study included 161,808 postmenopausal women enrolled between ...

phs000200.v7.p2 | EGA
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ProteomicsPrenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
The bactericidal function of neutrophils are dependent on myriad intrinsic and extrinsic stimuli. Us...
...TakTo, Jelena Milosevic, Rana Barghout, Abirami Kugadas, Xiaoxiao Lu, Jennifer Geddes-McAlister, Raina Fichorova, David B. Sykes, Mark D. Distefano, and Mihaela Gadjeva. 2023. Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities. Nat.Comm.
ORGANISM(S): Mus musculus (Mouse) 
2023-04-14 | PXD031115 | Pride
Neutrophil Prenylation Pcyox1l 
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TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-reg...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
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ProteomicsDiscovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus (Linn) F. Muell
Cyclotides are a family of plant-derived peptides characterized by a ~30 amino acid cyclic backbone and a cystine knot motif. Cyclotides have diverse bioactivities, and in particular their cytotoxicity has attracted significant attention for its potential anti-cancer applications. Hybanthus enneasper...
ORGANISM(S): Hybanthus enneaspermus 
2020-05-13 | PXD017924 | Pride
Anticancer property Surface plasmon resonance (spr) Peptide chemical synthesis Peptide-membrane interaction Nuclear magnetic resonance (nmr) Cyclotide Cancer cell cytotoxicity 
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