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ProteomicsLC-MS/MS of Versatile Decellularized Human Lung Extracellular Matrix-Derived Hydrogels
Decellularized ECM (dECM) hydrogels derived from human lungs can provide valuable insight into patient-specific and lung pathophysiology. Herein, we present the approach and some initial results that highlight the unique characteristics of this dECM hydrogel platform and its benefits for a variety o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-22 | MSV000090771 | MassIVE
ProteomicsA Comparative Proteomic Study of Decellularized Extracellular Matrix Biomaterials Derived from Porcine Vocal Fold and Small Intestinal Submucosa Tissue Source
Decellularized extracellular matrix (dECM) is used to make regenerative biomaterials. As the ECM markups vary across organs, derived dECM products may possess different molecular and biological profiles as well. This study aims to compare the proteomic profiles of dECM biomaterials derived from sma...
ORGANISM(S): Sus scrofa (Pig) 
2023-02-01 | PXD033621 | Pride
Vocal fold Porcine Small intestine submucosa Decellularized Decm Core matrisome Lc-ms/ms Extracellular matrix 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsCharacterisation of decellularized extracellular matrix hydrogels
This study investigated the development and characterization of decellularized extracellular matrix (dECM) hydrogels tailored for the bio-fabrication of female reproductive tissues, specifically targeting cortex, endometrium, medulla, and oviduct tissues. We aimed to evaluate the cytocompatibility, ...
ORGANISM(S): Bos taurus (Bovine) 
2026-03-12 | PXD053248 | Pride
Bio-ink Hydrogels In vitro models Reproductive system 
ProteomicsComparative proteomic analysis of the composition of decellularized extracellular matrix (dECM) and dECM-based inks as compared to the native tissue
Regenerative medicine and tissue engineering approaches based on the use of 3D-bioprinted decellularized extracellular matrix (dECM) present the advantage of a relatively biomolecule-rich matrix, which directs cell growth and differentiation in a tissue-specific manner. However, little is known abou...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-15 | PXD059171 | Pride
Ecm 3d bioprinting Ink composition Decellularization Lc–ms/ms 
ProteomicsBioactive decellularized extracellular matrix-based hydrogel supports human adipose tissue-derived stem cell maintenance and fibrocartilage phenotype
Decellularized extracellular matrix (dECM)-based hydrogels combined with hASCs could serve as an interface for studying behavior and differentiation properties in a cartilage microenvironment. In the present study, we described the behavior of hASCs cultured in a commercial dECM MatriXpec™. The prot...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-12-22 | PXD047464 | Pride
Cartilage Hydrogel Stem cells Extracellular matrix Decellularization 
TranscriptomicsDelineation of in vitro chondrogenesis of human synovial stem cells following preconditioning with decellularized matrix
As a tissue-specific stem cell for chondrogenesis, synovium-derived stem cells (SDSCs) are a promising cell source for cartilage repair. However, a small biopsy can only provide a limited number of cells. Cell senescence from both in vitro expansion and donor age presents a big challenge for stem ce...
ORGANISM(S): Homo sapiens 
2015-06-04 | E-GEOD-69531 | biostudies-arrayexpress
UnknownTailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation.
Not available
S-EPMC10209339 | biostudies-literature
ProteomicsChemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues
Investigating ECM-regulated new ECM production has been challenging due to the proteomic background from the pre-existing biomaterial ECM. To address this issue the newly synthesized ECM proteins (newsECM) of two different bioengineered tumor models were analyzed: tumor tissues, built upon decellula...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-08-30 | PXD061871 | Pride
Chemoselective chemistry Newly-synthesized extracellular matrix Biomaterial Proteomics 
UnknownRapid Volumetric Bioprinting of Decellularized Extracellular Matrix Bioinks.
Not available
S-EPMC11260906 | biostudies-literature
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