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ProteomicsFlow Cytometry Analysis of Circulating Extracellular Vesicle Subtypes from Fresh Body Fluids
Extracellular vesicles (EVs) are released by shedding during different physiological processes and are increasingly thought to be new potential biomarkers. However, the impact of pre-analytical processing phases on the final measurement is not predictable and, for this reason, the translation of bas...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD022807 | Pride
Extracellular vesicles  polychromatic flow cytometry  biomarkers  proteomics  fresh peripheral blood. 
ProteomicsProteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis
Several proteomics studies have been conducted to identify new cerebrospinal fluid (CSF) biomarkers in Multiple Sclerosis (MuS). However, the complexity of CSF and its invasive collection, limits its use. Therefore, the goal of biomarker research in MuS is to identify novel distinctive targets in CS...
ORGANISM(S): Homo sapiens (Human) 
2019-06-06 | PXD013794 | Pride
Proteomics  extracellular vesicles  facs sorting  csf  tears  multiple sclerosis. 
ProteomicsTransplantation of Telomerase/Myocardin Co-Expressing Mesenchymal Cells Promotes Revascularization and Tissue Repair in Murine Myocardial Infarction
Rationale and Objectives: Cellular therapies are hampered by poor survival and growth of grafts. We recently showed that the survival and repairing capacity of transplanted adult cells may be improved by co-expression of the anti-senescence telomerase reverse transcriptase (TERT) and anti-apoptotic ...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-02 | PXD017413 | Pride
Exosomes Adipose tissue–derived mesenchymal stromal cells  telomerase  myocardin  myocardial infarction Extracellular vesicles. 
ProteomicsSemaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma
Introduction Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. Although the therapies currently in use have proven effective, their use is limited by side effects arising and development of drug resistance. For this reason, re...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD065661 | Pride
Semaphorin 5a Melanoma Lamellipodia Focal adhesion 
ProteomicsProteomics investigation of Nucleostemin role in Nucleo-phosmin mutated OCI-AML 3 cell line
Nucleostemin (NS; product of the GNL3 gene) is a nucleolar/nucleoplasm shuttling GTPase whose levels are high in stem cells while rapidly decreasing upon differentiation. NS levels are also high in several solid and hematological neoplasms, including acute myeloid leukemia (AML). While a role in tel...
ORGANISM(S): Homo sapiens (Human) 
2022-08-11 | PXD034012 | Pride
Nucleophosmin Nucleostemin Shotgun proteomics Acute myeloid leukemia 
ProteomicsTear proteomics reveals the molecular basis of the efficacy of human recombinant nerve growth factor treatment for Neurotrophic Keratopathy
Neurotrophic Keratopathy (NK),classified as an orphan disease (ORPHA137596), is a rare degenerative corneal disease characterized by epithelial instability and decreased corneal sensitivity caused by the damage to the corneal nerves. The administration of human recombinant nerve growth factor (rhNGF...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD025408 | Pride
Proteomics  tear  neurotrophic keratopathy  ngf  extracellular vesicles 
ProteomicsFood-associated Lactiplantibacillus plantarum C9O4 reverts inflammation and apoptosis in intestinal epithelial cells: a proteomic insight
Nowadays, Western diets and lifestyle lead to an increasing occurrence of chronic gut inflammation, that represents an emerging health concern with still a lack of successful therapies. Fermented foods, and their associated Lactic Acid Bacteria, have recently regained popularity for their probiotic...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042175 | Pride
Lpb. plantarum c9o4 Inflammation pathway Proteomics Intestinal cells 
ProteomicsFACS-Proteomics strategy toward Extracellular Vesicles single-phenotype characterization in biological fluids: insights into the role of Leukocyte-derived EVs in Multiple Sclerosis
The isolation and proteomics characterization of Extracellular Vesicles (EVs) from body fluids represents a stimulating challenge to improve our knowledge of biology, considering the vast heterogeneity in terms of phenotype in vivo. Within a complex and dynamic scenario of EVs isolation and characte...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD049036 | Pride
Leukocyte-derived evs Multiple sclerosis Facs-proteomics Tears 
ProteomicsThe transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15R chain
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells also express a cleavable membrane-bound f...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD076097 | Pride
Il15 Cytokine Il15rα Skin cancer (melanoma) Natural killer (nk) cells 
ProteomicsProteomic analysis of Marinesco-Sjogren syndrome fibroblasts indicates pro-survival metabolic adaptation to SIL1 loss
Marinesco-Sjogren syndrome (MSS) is a rare multisystem pediatric disorder, caused by loss of function of the endoplasmic reticulum cochaperone SIL1 in about 60% of the patients. SIL1 acts as a nucleotide exchange factor for BiP, which plays a central role in secretory protein folding. SIL1-deficient...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD029086 | Pride
Autophagosome Protein folding Bip Pathway analysis Fibroblast Unfolded protein response Neurodegenerative disease 
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