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ProteomicsTRANSCRIPTIONAL ACTIVATION BY E2F4 INDEPENDENT OF THE RB FAMILY
E2F transcription factors are central regulators of cell cycle progression and cell fate decisions in mammalian cells. E2F4 is a transcriptional repressor implicated in cell cycle arrest and whose repressive activity depends on its interaction with members of the RB family. E2F4 often represents the...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-04-26 | PXD008796 | Pride
Rb Pluripotency Embryonic stem cells P130 E2f4 Cell cycle P107 
ProteomicsCEP19-RABL2 GTPase complex in ciliary transport
The mechanisms of how highly conserved intraflagellar transport (IFT) protein complexes direct ciliary entry remain unknown. Exploring human ciliopathy genes, including monogenic obesity syndrome genes, has been a rich source of critical ciliary mechanisms. Using AP-MS purification of interactors of...
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD006757 | Pride
Metabolic syndrome Gtpase Cep19-rabl2b complex Microtubules Bardet-biedl syndrome Proteomics Genetics" Obesity Ciliopathy Human genetics Centrosome Intraflagellar transport Centriole Cilia 
TranscriptomicsTranscription profiling of Campylobacter jejuni 11168 original vs. genome-sequenced, microaerobic and anaerobic conditions
Transcriptional analysis (RNA hybridization) for 11168-G (genome sequenced) vs. 11168-O (original), cultured microaerobically or anaerobically (published as "severely O2-limited). Published in Gaynor et al, J. Bacteriology 186:503-517
ORGANISM(S): Campylobacter jejuni 
2005-10-27 | E-SMDB-2525 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome
Not available
ORGANISM(S): Homo sapiens 
2006-06-06 | E-SMDB-2121 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome
Not available
ORGANISM(S): Homo sapiens 
2005-10-13 | E-SMDB-2119 | biostudies-arrayexpress
ProteomicsTHE FAM53C/DYRK1A AXIS REGULATES THE G1/S TRANSITION OF THE CELL CYCLE
A growing number of small molecules are becoming available to target the cell cycle machinery for the treatment of cancer and other human diseases. Consequently, a greater understanding of the factors regulating cell cycle progression becomes essential to help enhance to response of patients to thes...
ORGANISM(S): Homo sapiens (Human) 
2026-04-23 | PXD055829 | Pride
G1/s transition Cell cycle 
ProteomicsLKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the aggressi...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-23 | PXD026738 | Pride
Lung adenocarcinoma Mouse model Lkb1 Tumor suppressor 
ProteomicsMass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis
mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors
ORGANISM(S): Mus musculus (Mouse) 
2021-07-24 | PXD017442 | Pride
Hematopoiesis Early blood progenitors Stem cells Hematopoietic stem cells Aging 
ProteomicsSARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Emerging evidence points towards an intricate relationship between the pandemic coronavirus disease 2019 (COVID-19) and diabetes. While diabetes is associated with an increased risk of severe COVID-19, new-onset type 1 diabetes (T1D) has been observed in COVID-19 patients, convoluting diabetes as bo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-07-24 | PXD025629 | Pride
Pancreas Beta-cells Sars-cov-2 Human 
TranscriptomicsComparative genomic hybridization of pre- and post-mouse H. pylori strains SS1 and SS2000
This experiment set contains the raw data for 8 arrays that were used in the genomic typing of the pre- and post-mouse H. pylori strains SS1 and SS2000. 10700 is the pre-mouse clinical isolate of SS1 and PMSS2000 is the pre-mouse clinical isolate of SS2000. gDNA from these strains were labeled and h...
ORGANISM(S): Helicobacter pylori 
2005-11-03 | E-SMDB-1734 | biostudies-arrayexpress
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