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ProteomicsDiscovery of Thymosin beta-4 as a human exerkine and growth factor
Skeletal muscle has emerged as an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Via MS-based proteomics, we identified thymosin beta-4 (TMSB4X) to be the most upregulated secreted protein in the media of contracting C2C12 myotubes...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD024607 | Pride
Contraction Secreted factor Exercise Myokine Growth factor 
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
ProteomicsInsulin and 5-aminoimidazole-4-carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Skeletal muscle is a major contributor to whole-body glucose homeostasis and is an important endocrine organ. To date, few studies have undertaken the large-scale identification of skeletal muscle-derived secreted proteins (myokines), particularly in response to stimuli that activate pathways govern...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD025687 | Pride
Muscle Metabolism Insulin Secretome Aicar Lcms 
ProteomicsNovel tissue-specific markers revealed by in-depth proteome analysis of human myotendinous junction
Force is transmitted between skeletal muscle and tendon via a highly specialized tissue interface: the myotendinous junction (MTJ). Despite its crucial role in mechano-transduction and involvement in muscle strain injury, knowledge about the molecular composition of the MTJ is incomplete. We perform...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD029307 | Pride
Tendon Proteome Myotendinous junction Lc-ms/ms 
ProteomicsMass spectrometry-based analysis of the TBC1D4 interactome in human skeletal muscle
Insulin-stimulated muscle glucose uptake is a key process to alleviate hyperglycemia. This process depends on the redistribution of glucose transporters to the muscle surface membrane following phosphorylation of TBC1D1 and TBC1D4. Genetic evidence from a TBC1D4 loss-of-function mutation in human sk...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-03-01 | PXD026225 | Pride
Muscle Tbc1d4 Diabetes Insulin Interactome Lcms 
ProteomicsIntegrated liver and plasma proteomics in obese mice reveals complex metabolic and immune regulation
Obesity leads to the development of non-alcoholic fatty liver disease (NAFLD) and associated alterations to the plasma proteome. To elucidate the underlying changes associated with obesity, we performed liquid chromatography-tandem mass spectrometry in the liver and plasma of obese leptin-deficient ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD026821 | Pride
Proteome Ob/ob Obesity Lcms Nafld 
ProteomicsUnraveling the complexities of mitochondrial supercomplexes by mass spectrometry-based proteomics
It is now accepted that mitochondrial respiratory complex subunits assemble in supercomplexes. However, studying supercomplexes has typically relied upon antibody-based protein quantification, often limited to a single subunit per respiratory complex. To provide a deeper insight into mitochondrial p...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-17 | PXD016289 | Pride
Oxidative phosphorylation Mitochondrial supercomplexes Blue native gel Mitochondrial respiratory complexes Protein complex proteomics 
ProteomicsProteomics analysis of skeletal muscle from leptin-deficient ob/ob mice reveals adaptive remodeling of metabolic characteristics and fiber type composition
Skeletal muscle insulin resistance, an early metabolic defect in the pathogenesis of type 2 diabetes, may be a cause or consequence of altered protein expressions profiles. Proteomics technology offers enormous promise to investigate molecular mechanisms underlying pathologies, however, the analysis...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-26 | PXD007697 | Pride
Mouse skeletal muscle Obesity C2c12 muscle cells Lcmsms Diabetes 
ProteomicsIntegrated single cell functional-proteomic profiling of human skeletal muscle reveals a shift in cellular specificity in nemaline myopathy
Skeletal muscle is a complex syncytial arrangement of an array of cell types and, in the case of muscle specific cells (myofibers), sub-types. There exists extensive heterogeneity in skeletal muscle functional behaviour and molecular landscape, at the cell composition, myofiber sub-type and intra-my...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD061287 | Pride
Protein function-omics Nemaline myopathy Single muscle fiber 
ProteomicsSalivary Proteomics and Metaproteomics Identifies Distinct Molecular and Taxonomic Signatures Of Type 2 Diabetes
Background: Saliva is an attractive body fluid for non-invasive biomarker discovery, containing both human and microbial components, associated with various chronic diseases. Type-2 diabetes (T2D) imposes a significant health and socio-economic burden. Prior research on T2D salivary microbiome utili...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2025-05-06 | PXD051453 | Pride
Protein Peptide Metaproteomics Dia-pasef Microbiome Saliva Type-2-diabetes Biomarker Genus 
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