Sort   by:  
 Page size 
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Summary Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic activity. Paradoxically, PRC2 is essential in DMG tumo...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD047451 | Pride
Cprc1 H3k27me3 Pcgf4 H3k27m Cbx4 Diffuse midline glioma 
ProteomicsIdentification of Molecularly Targeted Therapy-Induced Immunopeptidome in Diffuse Midline Glioma (DMG)
We used MHC-I immunopeptidomics to study how MTX-241F, a selective EGFR/PI3K inhibitor, alters antigen presentation in diffuse midline glioma (H3K27M) and glioblastoma xenografts. MHC-I–bound peptides from vehicle- and drug-treated tumors were profiled by LC–MS/MS to identify tumor- and treatment-sp...
ORGANISM(S): Homo sapiens (Human) 
2026-02-10 | PXD070941 | Pride
Immunopeptidomics Dmg Mass spectrometry Epigenetic remodeling Gbm 
TranscriptomicsAffymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of paediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumours in children are identical to cereb...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-18828 | biostudies-arrayexpress
ProteomicsSpecific cPRC1 complexes are co-opted to mediate oncogenic gene repression in H3K27M-mutant diffuse midline glioma.
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting the enzymatic activity of the complex. Paradoxically, PRC2 histone methyltran...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD047401 | Pride
Glioma Epigenetics Prc2 
GenomicsPatch-seq of human patient-derived diffuse midline glioma xenografts
Patch-seq of human patient-derived diffuse midline glioma xenografts
PRJNA921869 | ENA
GenomicsActivity of PDGFRA inhibitor Avapritinib in H3K27M Diffuse Midline Glioma
Activity of PDGFRA inhibitor Avapritinib in H3K27M Diffuse Midline Glioma
PRJNA922137 | ENA
ProteomicsONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are the most lethal of all childhood cancers. Palliative radiotherapy is the only proven life-prolonging treatment, with patient survival 9-11 months. ONC201 shows preclinical and emerging clinical efficacy in DIPG. ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD036245 | Pride
Dmg Clpp agonist Targeted therapies Dipg Onc201 
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
ProteomicsH2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells
Diffuse intrinsic pontine gliomas (DIPG) are a deadly paediatric brain tumours, non-resectable due to brainstem localisation and diffusive growth. Patients with DIPG have a dismal prognosis of 9-12 months of survival with no effective therapy. Over 80% of DIPGs harbour a mutation in histone 3 (H3.3 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-05 | MSV000093052 | MassIVE
GenomicsH3K27-mutant diffuse hemispheric glioma presenting typical molecular features of diffuse midline glioma: A case report and literature review.
H3K27-mutant diffuse hemispheric glioma presenting typical molecular features of diffuse midline glioma: A case report and literature review.
PRJNA1209985 | ENA
Sort   by:  
 Page size