Sort   by:  
 Page size 
ProteomicsProximity proteomics of C9orf72 dipeptide repeat proteins
Profiling of proximity proteomes of C9orf72-derived dipeptide repeat proteins (poly-GA, poly-GR, poly-PR) in HEK293 cells using BioID assay
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-17 | MSV000088581 | MassIVE
GenomicsTranscriptional response of Corynebacterium glutamicum C1 to 3 mM indole-alanine dipeptide
Transcriptional response of Corynebacterium glutamicum C1 to 3 mM indole-alanine dipeptide
PRJNA670724 | ENA
ProteomicsThe Valine-Arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation
Translation of mammalian telomeric G-rich RNA via the Repeat Associated non-AUG translation mechanism can produce two dipeptide repeat proteins: repeating valine-arginine (VR) and repeating glycine-leucine (GL). Their potentially toxic nature suggests that to be retained through evolution, one or bo...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD054040 | Pride
Rna binding Mitosis Translation. Vr dipeptide 
ProteomicsCharacterization of the cyclic dipeptide cyclo(His-Pro) in Arabidopsis
The iTSA experiment was designed to map putative protein targets of cyclic dipeptides in Arabidopsis.
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2025-04-17 | MSV000097655 | MassIVE
TranscriptomicsTranscriptional response of Corynebacterium glutamicum C1 to 3 mM indole-alanine dipeptide
Differential gene expression analysis of C. glutamicum C1 in presence of 3 mM indole-alanine dipeptide compared to control conditions without indole-alanine dipeptide. C. glutamicum C1 cells were cultivated in CGXII minimal medium with 40 g per litre glucose in presence or absence of 3 mM indole-ala...
ORGANISM(S): Corynebacterium glutamicum 
2020-12-31 | GSE159888 | GEO
ProteomicsPhase separation of C9orf72 dipeptide repeats perturbs stress granule metabolism
Liquid-liquid phase separation (LLPS) of RNA binding proteins underlies the formation of multiple membraneless organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a corner stone of ALS/FTLD pathogenesis. Phase separation of ALS-linked st...
ORGANISM(S): Homo sapiens (Human) 
2017-04-26 | PXD005509 | Pride
Stress granules Labelfree shotgun proteomics Arginine-rich dipeptide repeats Liquid-liquid phase separation 
ProteomicsCharacterization of the cyclic dipeptide cyclo(His-Pro) in Arabidopsis
The cyclic dipeptide cyclo(His-Pro) binds to and inhibits the activity of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase in Arabidopsis, affecting plant stress tolerance.
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2025-03-19 | MSV000097377 | MassIVE
ProteomicsInteractome screening of C9orf72 dipeptide repeats reveals sequestration and functional impairment of VCP by polyGA
Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation to produce unnatural dipeptide rep...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD024120 | Pride
Proximity labeeling Proteomics Amyotrophic lateral sclerosis Als Valosin-containing protein Vcp Bioid Neurodegeneration Dipeptide repeats 
ProteomicsA global map of protein–metabolite interactions in budding yeast reveals a novel role of a proteogenic dipeptide Ser-Leu in the regulation of a key glycolytic enzyme Pgk1.
Protein-metabolite interactions (PMIs) are of crucial importance for all cellular processes but remain understudied. Here, we applied a novel biochemical approach named PROMIS, to address the complexity of the protein-small molecule interactome in the model yeast Saccharomyces cerevisiae. By doing s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-26 | PXD021530 | Pride
Complexes Dipeptide Yeast Pgk1 Small molecule Promis Ligand Protein–metabolite interaction Glycolysis Central metabolism Purine degradation 
ProteomicsInteractome of C9orf72 arginine-rich dipeptide proteins
A GGG GCC hexanucleotide repeat expansion within the C9orf72 gene is the most common genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and antisense repeat-containing transcripts undergo repeat associated non-AUG-initiated translation to produce five dipeptide pr...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-01-07 | PXD012099 | Pride
Ap-ms Brain Orbitrap Drosophila Lc-ms/ms 
Sort   by:  
 Page size