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ProteomicsA synthetic crosslinked peptide library for benchmarking crosslinking mass spectrometry search engines
We have created a synthetic crosslinked peptide library to benchmark crosslinking mass spectrometry search engines. The unique benefit of the library is knowing which identified crosslinks are true and which are false. The data collected from mass spectrometry measurements of the peptide library wer...
ORGANISM(S): Streptococcus pyogenes ABC020006030 
2020-07-28 | PXD014337 | Pride
Crosslinking mass spectrometry peptide library 
ProteomicsCrosslinking mass spectrometry dataset for mzIdentML 1.3 validation with MeroX 2.0.2.5
This dataset was generated to support the validation of mzIdentML 1.3 files, including the crosslinking extension. The dataset contains LC-MS/MS data and crosslinking search results for DSBU-crosslinked peptides, together with mzIdentML 1.3 files containing crosslinking-specific annotations and cont...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD077188 | Pride
Xl-ms Mzidentml 
UnknownMapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
Not available
S-EPMC8137598 | biostudies-literature
ProteomicsPRR of Tau Crosslinking with Tubulin
We used cross-linking mass spectrometry with the cleavable cross-linker, disuccinimidyl dibutyric urea (DSBU) to map sites of interaction between the proline rich domain (PRR, tau amino acids 149-244) and tubulin. For comparison, we also conducted these experiments with PRR constructs containing mul...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2026-03-09 | PXD049384 | Pride
Tubulin Tau Phosphorylation Proline rich region 
ProteomicsCrosslinking MS analysis of GST-M18BP1(312-490) and CENP-HIKM using DSBU
Crosslinking mass spectrometry was performed to identify intermolecular DSBU crosslinks between GST-M18BP1(312-490) and the CENP-HIKM complex. The study aimed to map the binding interface of CENP-HIKM and M18BP1, comparing wild-type and a 355-359A M18BP1 mutant that no longer binds CENP-HIKM.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-11-06 | MSV000099772 | MassIVE
ProteomicsCrosslinking MS analysis of CDK1-phosphorylated GST-M18BP1(312-490) and MBP-CENP-C(601-943) using DSBU
Crosslinking mass spectrometry was performed to identify intermolecular DSBU crosslinks between CDK1-phosphorylated GST-M18BP1(312-490) and MBP-CENP-C(601-943). The aim was to map the binding interface between CENP-C and M18BP1.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-11-06 | MSV000099773 | MassIVE
ProteomicsXL-MS data analysis with MeroX and XlinkX
Comparison of MeroX in different modes and XlinkX upon variation of database size based on DSBU linked BSA as test-dataset
ORGANISM(S): Bos taurus (Bovine) 
2020-11-17 | PXD021648 | Pride
Mass-spectromerty Dsbu Xlinkx Merox Crosslinking Bsa 
ProteomicsImproved peptide backbone fragmentation is the primary advantage of MS-cleavable crosslinkers
Proteome-wide crosslinking mass spectrometry studies have coincided with the advent of MS-cleavable crosslinkers that can reveal the individual masses of the two crosslinked peptides. However, recently such studies have also been published with non-cleavable crosslinkers suggesting that MS-cleavabil...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli Drosophila melanogaster (Fruit fly) 
2022-06-24 | PXD032821 | Pride
Lc-msms Dsbu Ms-cleavable crosslinker Dsso Crosslinking Clms 
ProteomicsInvestigation of interaction of p97, p37, PPI, SDS22 and Inhibitor-3 using cross-linking mass spectrometry (CL-MS)
In this project we investigated the complexes PPI/SDS22/Inhibitor-3 and p97/p37/PPI/SDS22/Inhibitor-3 by CL-MS using DSBU as crosslinker.
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD026696 | Pride
Dsbu Ppi Inhibitor-3 Sds22 P97 
ProteomicsComprehensive identification of crosslinked peptides from methyltransferase Hmt1 and its substrate Npl3: use of multiple crosslinkers, mass spectrometry approaches and software platforms
Chemical-Crosslinking Mass Spectrometry (XLMS) using MS-cleavable crosslinkers is fast becoming an established technique in the study of protein-protein interactions for both small and large scale samples. With the increased uptake of XLMS as a technique, different combinations of crosslinker types,...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2018-07-20 | PXD008348 | Pride
Crosslinking-mass spectrometry Ms-cleavable linkers 
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