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ProteomicsBSO and Auranofin Redox ICAT: Dataset of peptide identification results from a Redox ICAT experiment including rawfiles from LTQ-Orbitrap XL
In the current study, we used a mass spectrometry-based redox proteomics approach to test responses of the cysteine (Cys) proteome to selective disruption of the Trx- and GSH-dependent systems. Auranofin (ARF) was used to inhibit Trx reductase without detectable oxidation of the GSH/GSSG couple, and...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD000353 | Pride
Bso Auranofin Mass spectrometry Redox Icat Proteomics 
ProteomicsPosttranslational modifications mediate the structural diversity of tauopathy strains
Tau aggregation is the defining pathological hallmark of tauopathies, but structural insights are revealing key differences between filaments across this class of disorders. Using cryo-electron microscopy, we identify a 107-residue fragment, K274-E380, which forms the insoluble core of tau filaments...
ORGANISM(S): Homo sapiens (Human) 
2020-02-14 | PXD016862 | Pride
Cbd Tau Mass spectrometry 
ProteomicsGlobal quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
Patients with Alzheimer’s disease (AD) and Parkinson disease (PD) often have overlap in brain neuropathology and clinical presentation suggesting that these two diseases share common underlying mechanisms. Currently, the molecular events linking AD and PD are incompletely understood. Utilizing 10-p...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD007160 | Pride
Brain Tmt Human Sps Parkinson's Alzheimer's Lc-ms/ms 
ProteomicsAllele-Specific Protein Abundance in Human Brain
We describe a method for identifying peptides that result from missense changes and identify peptides among 2 human brains that would have otherwise not been detected. Next, we use this data to estimate of allele-specific protein abundance in human brain for an average per individual, and to estimat...
ORGANISM(S): Homo sapiens (Human) 
2017-07-31 | PXD004143 | Pride
Proteogenomics genomics variants proteomics 
ProteomicsQuantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1
GPR37 and GPR37L1 are glia-enriched GPCRs that have been implicated in several neurological and neurodegenerative diseases. To gain insight into the potential molecular mechanisms by which GPR37 and GPR37L1 regulate cellular physiology, proteomic analyses of whole mouse brain tissue from wild-type (...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-13 | PXD015202 | Pride
Mice lfq gpr37 
ProteomicsDeng Lab RRM2 Acetylation Study
RRM2 Acetylation Mass Spectrometry Data including PD result files, raw mass spectrometry data and curated results.
ORGANISM(S): Homo sapiens (Human) 
2019-07-18 | PXD014105 | Pride
Deng rrm2 acetylation 
ProteomicsOrthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2, and ubiquitin ligase E3. Uba1 was thought to be the only E1 until the recent identification of Uba6 as an alternative. To differentiate the biological functions of Uba1 and Uba6, we ap...
ORGANISM(S): Homo sapiens (Human) 
2017-07-31 | PXD005513 | Pride
Lc-msms Ubiquitination Ubiquitin 
ProteomicsCell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain
Proteomic profiling of brain cell types using isolation-based strategies pose limitations in resolving cellular phenotypes representative of their native state. We generated a novel mouse line for cell type-specific expression of biotin ligase TurboID, leading to in vivo biotinylation of proteins. U...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-28 | PXD032161 | Pride
Mouse Brain Proteomics Lc-ms/ms 
ProteomicsCell type-specific in vivo proximity labeling of the neuronal proteome reveals regional differences in mouse brain.
Isolation and proteomic profiling of brain cell types, particularly neurons, pose several technical challenges which limit our ability to resolve distinct cellular phenotypes in neurological diseases. Therefore, we generated a novel mouse line that enables cell type-specific expression of a biotin l...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-28 | PXD027488 | Pride
Mass spectrometry Mouse Proteome Lc-ms/ms Turboid 
ProteomicsAdaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain, causing seizures and neurodegeneration in infancy through poorly understood mechanisms. Here, we used multiple model systems to characterize the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059097 | Pride
Tmt Neurodegeneration Mtor 
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