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TranscriptomicsMolecular consequences of Dlx3 deletion in mouse enamel organ as determined by RNASeq analysis
DLX3 is a homeodomain transcription factor involved in ameloblast differentiation and enamel formation. Mutations in DLX3 in human lead to defects in enamel. However, the downstream targets of Dlx3 transcriptional activity in the enamel organ have not been identified yet. In this study, we compared ...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-57984 | biostudies-arrayexpress
ProteomicsEnamel proteome shows that Gigantopithecus was an early diverging pongine
Gigantopithecus blacki was a giant hominid that inhabited Southeast Asia during the Pleistocene. Its evolutionary relationship to other great ape species, and their divergence during the Middle and Late Miocene (16-5.3 Mya), remains disputed. In part, this is due to the absence of cranial and postcr...
ORGANISM(S): Hominidae 
2019-11-12 | PXD013838 | Pride
Enamel Pleistocene Gigantopithecus Lc-msms 
ProteomicsAutomated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics
Biological sex is a key information for archaeological and forensic studies, which can be assessed in enamel using proteomics. However, the lack of a standard approach for fast and accurate sex identification limits the reach of proteomics applications. Here, we introduce a targeted proteomics-based...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD049326 | Pride
Forensics Prm Sex Palaeoproteomics Archaeology Enamel 
TranscriptomicsTranscription profiling of mouse incisor tooth germ to associate changes in levels of mRNAs with development of enamel structure
The tooth is a convenient experimental model for the study of the basic mechanisms of organ development, including differentiation, cellular interaction, morphogenesis, and production and mineralization of extracellular matrices. The rodent incisor teeth grow continuously and exhibit all stages of t...
ORGANISM(S): Mus musculus 
2010-10-01 | E-MTAB-149 | biostudies-arrayexpress
ProteomicsThe TNH2 hominin enamel proteome
Here we analyse two enamel protein extractions from a Middle Pleistocene hominin from Laos, Asia. The proteome is analyzed for potential phylogenetic information and characterized in terms of its molecular damage and in vivo (serine) phosphorylation.
ORGANISM(S): Homo 
2022-04-06 | PXD018721 | Pride
Enamel Lc-ms/ms Phosphorylation Palaeoproteomics 
ProteomicsAncient tooth enamel proteomes to help understand post mortem protein degradation over millions of years
The tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as t...
ORGANISM(S): Equidae Proboscidea <placentals> 
2025-05-06 | PXD048972 | Pride
Proboscidea Paleoproteomics Equidae Ancient Enamel 
ProteomicsA Pleistocene hominin enamel proteome from Homo antecessor
Hominin relationships and their dispersal throughout Eurasia during the Early and Middle Pleistocene are highly debated. The relationships between Early and Middle Pleistocene hominins, like Homo antecessor and Homo erectus, and hominin species that dominate the Late Pleistocene fossil record, like ...
ORGANISM(S): Homo 
2020-04-02 | PXD014342 | Pride
Enamel Hominins Phosphorylation Palaeoproteomics Lc-ms/ms 
ProteomicsEnamel proteins reveal biological sex and intrataxon variability within Paranthropus robustus
The evolutionary relationships among extinct African hominin species are highly debated and largely unresolved, due in part to a lack of molecular data. Even within taxa, it is not always clear, based on morphology alone, whether ranges of variation are due to sexual dimorphism versus potentially un...
ORGANISM(S): Homo 
2025-06-09 | PXD040221 | Pride
Human evolution Sequence reconstruction Dental enamel Palaeoproteomics Enamel 
ProteomicsSex estimation of human remains using the results of tooth enamel peptidomic analyses, LC-MSMS
Sex of individuals, estimated on human remains, is important information in anthropological, archaeological and forensic researches. In forensic anthropology, this is one of the key points for identifying a person. In archeology and paleoanthropology, information about sex is important for reconstru...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD017965 | Pride
Amelogenins Lc-msms Sex estimation Peptides Tooth enamel 
ProteomicsHuman enamel peptides LC-MS/MS.
Recently, enamel peptides revealed their critical role in sex classification of old skeletal remains. In particular, the presence of protein AMELY (amelogenin isoform Y) within the enamel dental tissue is restricted to the male sex only, while AMELX (isoform X) can be found in both sexes. AMELY can ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-05 | PXD012587 | Pride
Human Enamel Sex Peptides Archaeology 
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