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The aim of this experiment was to get a comparison of the signatures between a non-transformed cell (NIH3T3 + vector) and a transformed cell (NIH3T3 + Fbxo7). NIH3T3 cells become transformed after the stable integration of the Fbxo7 gene. Fbxo7 potentiates cyclin D/cdk6 activity.
ORGANISM(S): Mus musculus 
Triplicate FLAG-Immunoprecipitations of FLAG-tagged FBXO7 constructs (full length (1-522), ∆N (169-522), ∆C (1-406), and ∆N∆C (169-406)) overexpressed in FBXO7-/- PSMF1-/- HEK293T cells. FBXO7∆N∆C co-overexpressed with full length PI31(1-271) is also included. Parental cells lacking tagged FBXO7 are...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077028 | Pride
Analysis of a conditional knockout of Fbxo7/Park15 expression in mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2019-08-28 | PXD011666 | Pride
Triplicate FLAG-Immunoprecipitations of FLAG-tagged FBXO7 overexpressed in FBXO7-/- PSMF1-/- HEK293T cells co-overexpressed with full length PI31(1-271), PI31∆PRR (1-151), or without PI31 (empty vector). wild type HEK293T containing FLAG-tagged eGFP samples represent a negative control IP Identities...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077448 | Pride
RNA-seq of FBXO7 knockdown in breast cancer cell line
Triplicate HA-Immunoprecipitations of HA-tagged PI31 variants including full length (1-271), FP domain (1-151) and Parkinson's associated sequence variants, L53M, L228V, R231X(1-230), R242G, R242C, overexpressed in FBXO7-/- PSMF1-/- HEK293T cells co-overexpressed with full length FBXO7(1-522), or wi...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD077016 | Pride
The protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed-forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin activation, and ubiquitylation of mitochondrial outer membrane proteins to support recruitment of mitophagy receptors. The ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD037797 | Pride
RNA-seq of FBXO7 knockdown in breast cancer cell line
ORGANISM(S): Homo sapiens 
2022-03-22 | GSE155978 | GEO
Cell lysate from HAP1 cells were separated on several columns, the proteins were digested with trypsin and analysed on a Q Exactive HF-X instrument.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-05 | MSV000085912 | MassIVE
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