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Analysis of a conditional knockout of Fbxo7/Park15 expression in mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2019-08-28 | PXD011666 | Pride
The protein kinase PINK1 and ubiquitin ligase Parkin promote removal of damaged mitochondria via a feed-forward mechanism involving ubiquitin (Ub) phosphorylation (pUb), Parkin activation, and ubiquitylation of mitochondrial outer membrane proteins to support recruitment of mitophagy receptors. The ...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD037797 | Pride
Mutations in PARK15, which encodes for the F-box protein FBXO7 have been associated with Parkinsonian Pyramidal syndrome, a rare and complex movement disorder with Parkinsonian symptoms, pyramidal tract signs and juvenile onset. Our previous study showed that systemic loss of Fbxo7 in mice causes mo...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-18 | PXD044119 | Pride
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