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ProteomicsTranscriptional determinants of lipid mobilization in human adipocytes
Defects in white adipose tissue lipolysis drive multiple aspects of cardiometabolic disease but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen in primary human adipocytes. Our analyses identified 37 transc...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD046964 | Pride
Coronary artery disease Lipolysis Type 2 diabetes Phosphodiesterase Znf189 Cad Pde1b2 T2dm Chip 
ProteomicsA network-based approach reveals a novel mechanism of resistance to TKI-therapy in AML
Internal tandem duplications (ITDs) in the FLT3 gene are frequently identified and confer a poor prognosis in patient affected by acute myeloid leukemia (AML). The insertion site of the ITDs in FLT3 significantly impacts the sensitivity to tyrosine kinase inhibitors (TKIs) therapy, affecting patient...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD033953 | Pride
Tyrosine kinase inhibitors Ba/f3 cells Acute myeloid leukemia Midostaurin Flt3 Mouse Phosphoproteomics Tki Quizartinib Aml 
TranscriptomicsHost cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia
Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involveme...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-33731 | biostudies-arrayexpress
ProteomicsTranscriptional regulation of ER-phagy by MiT/TFE factors controls chondrocyte differentiation and bone formation
Lysosomal-autophagic degradation of Endoplasmic Reticulum via autophagy (ER-phagy) is emerging as critical regulator of ER homeostasis and function. However, the molecular mechanisms governing ER-phagy are still unknown. Working in chondrocytes, we found that ER-phagy and lysosome biogenesis are co-...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015331 | Pride
Phosphoprotemics Fgf signaling Er-phagy 
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