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UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
MetabolomicsRA-MAP: mapping the molecular immunological landscape in early rheumatoid arthritis with vaccine controls

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of RA, we performed comprehensive clinical and molecu...

2021-06-16 | MTBLS1497 | MetaboLights
ProteomicsIntegrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056848 | Pride
3d Chromatin Proteomics Epigenetics Resistance Her2 Lc-ms/ms 
ProteomicsOncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism
Genetic alterations that activate protein kinase A (PKA) signaling are found across many tumor types, but their downstream oncogenic mechanisms are poorly understood. We used global phosphoproteomics and kinome activity profiling to map the conserved signaling outputs driven by diverse genetic chang...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD025508 | Pride
Aurka Fibrolamellar carcinoma Pim2 Pka Myc Liver cancer 
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownCausal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Not available
S-EPMC3564800 | biostudies-literature
ProteomicsKRASG12C inhibition produces a driver-limited state revealing collateral dependencies
Inhibitors targeting KRASG12C are a promising new class of oncogene-specific therapeutics for the treatment of tumors driven by KRASG12C mutations. These molecules react with the mutant cysteine residue by binding covalently to the switch-II pocket present only in the inactive-GDP state of KRASG12C,...
ORGANISM(S): Homo sapiens (Human) 
2020-03-23 | PXD013075 | Pride
Kras Lung cancer Pancreatic cancer 
UnknownEnamel-dentine junction morphology reveals population replacement and mobility in the late prehistoric Middle Nile Valley.
Not available
S-EPMC12012513 | biostudies-literature
TranscriptomicsExpression profiling of 275 lung cancer specimens
From ~1,700 non-small cell lung cancer specimens collected at the MD Anderson Cancer Center over the years 1997 to 2005, we selected 914 tumors with detailed clinical and pathological information. We extracted RNA and DNA from frozen tissues using histology quality control from 700 cases. RNA was ex...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-41271 | biostudies-arrayexpress
ProteomicsDissection of affinity captured LINE-1 macromolecular complexes
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive and others required for the L1 lifecycle. Using dif...
ORGANISM(S): Homo sapiens (Human) 
2018-01-17 | PXD008542 | Pride
Line-1 Protein interactions Affinity proteomics L1 Mass spectrometry Biochemistry Retrotransposon Ribonucleoprotein Rnp Interactome 
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