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TranscriptomicsCharacterization of the transcriptional response to hypoxia in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxic or normoxic conditions
To interrogate the hypoxia response pathways affected by the depletion of CAIX in BC cells, we performed gene expression profiling using SurePrint G3 Human Gene Expression 60K microarrays in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxi...
ORGANISM(S): Homo sapiens 
2018-01-01 | E-MTAB-5512 | biostudies-arrayexpress
ProteomicsThe melanoma cell line MDA-MB-435 adhesome in long-term culture and its comparison to the adhesome upon integrin αV knockdown
Using mass spectrometry–based proteomics, we analysed the components of integrin adhesion complexes of MDA-MB-435S cells and two MDA-MB-435S-derived integrin αV-specific shRNA-expressing cell clones. Among integrins, we detected αV and β5 integrin subunits in the MDA-MB-435S adhesome, thus showing t...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD016837 | Pride
Human Cancer Mda-mb-435s Integrin adhesion complex Adhesome Integrin αvβ5 Melanoma Cortical microtubule stabilisation complex 
ProteomicsThe MICOS-MIB complex member PERM1 connects mitochondria with the sarcolemma via ankyrin B
Skeletal muscle subsarcolemmal mitochondria (SSM) and intermyofibrillar mitochondria subpopulations have distinct metabolic activity and sensitivity, though the mechanisms that localize SSM to peripheral areas of muscle fibers are poorly understood. A protein interaction study and complexome profili...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-16 | PXD025745 | Pride
Mitochondria  skeletal muscle  perm1  proteomics 
ProteomicsThe effect of cannabinoid receptor agonists on triple-negative breast cancer cell line (MDA-MB-231)
The endocannabinoid system (ECS) provides regulatory functions in several cellular and physiological processes. It has also been found to play a role in control of cancer development. Our group found that breast cancer cells responded to cannabinoid receptor (CB) agonist treatments. This leads the a...
ORGANISM(S): Homo sapiens (Human) 
2024-07-27 | PXD040666 | Pride
Breast cancer Triple-negative Proteomics Cannabinoid receptor agonists Human Endocannabinoid 
MetabolomicsCE-MS Metabolomic and LC-MS Proteomic Analyses of Breast Cancer Exosomes Reveal Alterations in Purine and Carnitine Metabolism

A nano sheath-flow capillary electrophoresis mass spectrometry (CE-MS) system with electrospray ionization was used to profile cationic metabolite cargo in exosomes secreted by non-tumorigenic MCF-10A and tumorigenic MDA-MB-231 breast epithelial cells. CE-MS-based metabolomics revealed increased ...

2024-11-14 | MTBLS11190 | MetaboLights
ProteomicsThe value of subcellular fractionation for protein identification in a B-cell line (Ramos)
Integrated in the Chromosomic-centric Human Proteome Project (C-HPP), a lymphocytic B-cell line (Ramos) was selected as a model of B-cells. We performed a subfractionation strategy (in triplicate) for the extraction of proteins from 4 different fractions (cytoplasm, CYT; organella, ORG; membrane, MB...
ORGANISM(S): Homo sapiens (Human) 
2015-08-04 | PXD001933 | Pride
Cytoplasm B-cell Human Organella Nucleus Orbitrap Ramos Membrane 
ProteomicsProteome of Control versus shKDM2B in MDA-MB-231 Cells
Project comparing the proteome between control and knockdown of KDM2B in MDA-MB-231 cell lines. Previous data demonstrated that knockdown of KDM2B induced transcriptional changes in ribosomal and metabolic gene targets and thus TMT proteomics was pursued to compare the protein level changes that occ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-22 | PXD046970 | Pride
Human Breast cancer Tmt proteomics Mda-mb-231 Kdm2b 
MetabolomicsCTH exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have highlighted the importance of macrophage immunometabolism in their activation state and function...
2022-06-14 | MTBLS2851 | MetaboLights
TranscriptomicsAcquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways”
Two breast cancer cell lines, MCF-7 and MDA-MB-213, were treated progressively with docetaxel.
ORGANISM(S): Homo sapiens 
2014-09-01 | E-MEXP-3982 | biostudies-arrayexpress
TranscriptomicsBone morphogenetic protein-7 is a MYC target with pro-survival functions in childhood medulloblastoma
Medulloblastoma (MB) is the most common malignant brain tumor in children, among whom overexpression or amplification of MYC oncogenes has been associated with poor clinical outcome. Although the MYC functions during normal development and oncogenesis in various systems have been extensively investi...
ORGANISM(S): Homo sapiens 
2011-05-16 | E-GEOD-22139 | biostudies-arrayexpress
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