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MetabolomicsSex-dependent metabolic remodeling of kidneys revealed by arteriovenous metabolomics

Sex is a fundamental biological variable important in biomedical research, drug development, clinical trials, and prevention approaches. Among many organs, kidneys are known to exhibit remarkable structural, histological, and pathological differences between sexes. However, whether and how kidney...

2026-03-04 | MTBLS13977 | MetaboLights
TranscriptomicsA microRNA network regulates expression and biosynthesis of CFTR and CFTR-M-NM-^TF508.
Production of functional proteins requires multiple steps including gene transcription and post-translational processing. MicroRNAs (miRNA) can regulate individual stages of these processes. Despite the importance of the cystic fibrosis transmembrane conductance regulator (CFTR) channel for epithe...
ORGANISM(S): Homo sapiens 
2012-09-04 | E-GEOD-38956 | biostudies-arrayexpress
ProteomicsGlycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease (PD) ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD032832 | Pride
Brain Parkinson's disease Glycation 
TranscriptomicsRNA sequencing of Mycobacterium abscessus under infection-relevant conditions
RNA sequencing (RNA-seq) of Mycobacterium abscessus in four infection-relevant culture conditions: hypoxic stress, artificial sputum medium, kanamycin-treated medium, and erythromycin-treated medium. Triplicate cultures of M. abscessus were grown in (1) Artificial Sputum media, (2) hypoxic condition...
ORGANISM(S): Mycobacterium abscessus 
2016-03-02 | E-GEOD-78787 | biostudies-arrayexpress
TranscriptomicsIntestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation [mRNA]
The host response to S.typhimurium infections in ileum was studied after infection of piglets. mRNA and miRNA expression studies were performed to identify interactions of miRNAs and regulated mRNAs in context of mammalian intestinal Salmonella infection using a piglet model. Intestinal samples (~ 2...
ORGANISM(S): Sus scrofa 
2013-06-25 | E-GEOD-40804 | biostudies-arrayexpress
TranscriptomicsDynamic regulation of microRNA expression following Interferon-gamma-induced gene transcription
MicroRNAs are major regulators of post-transcriptional gene regulation. Even small changes in miRNA levels may have profound consequences for the expression levels of target genes. Hence, miRNAs themselves need to be tightly, albeit dynamically, regulated. Here, we investigated the dynamic behaviour...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-MEXP-3544 | biostudies-arrayexpress
ProteomicsGlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome
Immature O-glycosylation, characterized by the Tn antigen expression rather than complex glycans, is prevalent in advanced solid tumors and promotes immune evasion. We developed GlycoAvatars, magnetic beads coated with plasma-membrane glycoproteins from glycoengineered cancer cell models, to identif...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD060750 | Pride
TranscriptomicsDifferential expression of microRNAs between oral squamous cell carcinoma and healthy control tongues
In order to identify aberrantly expressed microRNAs in oral squamous cell carcinomas (OSCCs), we have employed microRNA microarray profile using healthy tongue samples as control. All seventeen human OSCCs and three normal tongue tissues were collected from the Tissue Bank at the Moffitt Cancer Cent...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-28100 | biostudies-arrayexpress
TranscriptomicsmiR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8
miR-93/106b and their host gene minichromosome maintenance complex component 7 (MCM7) reside at chr7q22, a region frequently rearranged in leiomyomas. We explored the expression of miR-93/106b in leiomyoma and paired myometrium (N=62) from untreated and patients exposed to hormonal therapies (GnRHa,...
ORGANISM(S): Homo sapiens 
2012-04-09 | E-GEOD-37122 | biostudies-arrayexpress
ProteomicsInteractome of the -subunit of L-type voltage-gated calcium channels in adult cardiomyocytes
In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction coupling. LTCCs are heteromultimeric proteins compose...
ORGANISM(S): Rattus rattus (Black rat) 
2021-12-14 | PXD021375 | Pride
Dstorm Ca2+ influx Proteomics L-type voltage-gated calcium channels (ltccs) Nano-environments of cav2 Pull-down Cardiomyocytes 
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