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ProteomicsPodocyte Focal Adhesion Proteome
Expression proteomics analysis of focal adhesion complexes isolated from a human immortalized podocyte cell line.
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD010626 | Pride
Human Podocyte Glomerulus Kidney Lc-ms/ms 
OtherProteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.
Data from ProteomeXchange, PXD ID: PXD001800. File: 6H_02.mzml. Published as part of Exp Eye Res. 2015 Jun 15;138:87-95 . From the Abstract: {{i}} Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidate...
ORGANISM(S): Pig 
GPM32320017441 | GPMDB
Resource Reanalysis 
TranscriptomicsFocal Adhesion Kinase Dependent Expression
The goal of this study was to identify transcripts, which are differentially regulatulated in the presence and absence of Focal Adhesion Kinase. As Focal Adhesion Kinase activity can depend upon cell density (Snijder et al. Nature 2009), biological replicates where cells, were seeded very sparsely o...
ORGANISM(S): Mus musculus 
2013-09-17 | E-GEOD-43873 | biostudies-arrayexpress
ProteomicsSemaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma
Introduction Metastatic potential and rising incidence make cutaneous melanoma a major health concern worldwide. Although the therapies currently in use have proven effective, their use is limited by side effects arising and development of drug resistance. For this reason, re...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD065661 | Pride
Semaphorin 5a Melanoma Lamellipodia Focal adhesion 
ProteomicsEffect of TPA on focal adhesion composition
Effect of a tumor promoter TPA on collagen IV based focal adhesions from CHO cells expressing human integrin alpha1 with activating mutation E317A
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2016-07-11 | PXD003153 | Pride
Focal adhesions Cho cells Lc-ms/ms 
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080089 | MassIVE
ProteomicsThe Itgb3 Adhesome - Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature
Integrin β3 is seen as a key anti-angiogenic target for cancer treatment due to its expression on neovasculature, but the role it plays in the process is complex; whether it is pro- or anti-angiogenic depends on the context in which it is expressed. To understand precisely β3’s role in regulating i...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-23 | PXD008591 | Pride
Angiogenesis Vasculature Cell adhesion Focal adhesions Endothelial cells Cancer Microtubules Cell migration Integrins 
TranscriptomicssiRNA profiling if human MCF-7 cell line to investigate the role of FAK, dominant-negative FAK, FAK-CD and FAKsiRNA in MCF-7 human breast cancer cell tumorigenesis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...
ORGANISM(S): Homo sapiens 
2009-08-22 | E-GEOD-11581 | biostudies-arrayexpress
TranscriptomicsEarly Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression
Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays t...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16873 | biostudies-arrayexpress
ProteomicsRemodeling of the focal adhesion complex by hydrogen-peroxide- induced senescence
Cellular senescence is a phenotype characterized by cessation of cell division, which can be caused by exhaustive replication or environmental stress. It is involved in age-related pathophysiological conditions and affects both the cellular cytoskeleton and the prime cellular mechanosensors, focal a...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-06 | PXD041766 | Pride
Lc-ms Oxidation Senescence 3t3 cell line 
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