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ProteomicsCD4+ Th immunogenicity of Ascaris spp.
Application of a reconstituted in vitro system to define the CD4+ Th immunogenicity of complex antigenic mixtures.
ORGANISM(S): Homo sapiens (Human) Ascaris suum 
2020-03-04 | PXD015012 | Pride
Cd4+ th epitope Mhcii Ascaris In vitro 
ProteomicsCD4+ Th immunogenicity of Ascaris spp.
Application of a reconstituted in vitro system to define the CD4+ Th immunogenicity of complex antigenic mixtures.
ORGANISM(S): Ascaris suum 
2020-03-04 | PXD015924 | Pride
Cd4+ t cell epitope/ immunodominance/ immunogenicity/ mhcii antigen presentation/ ascaris spp./ pathogen 
ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018703 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
ProteomicsDynamic Palmitoylation Events Following T-Cell Receptor Signaling
Palmitoylation is the reversible addition of palmitate to cysteine via a thioester linkage. The reversible nature of this modification makes it a prime candidate as a mechanism for regulating signal transduction in T-cell receptor signaling. Following stimulation of the T-cell receptor we find a num...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018710 | Pride
Lat Dhhc20 Palmitoylation S-acylation Ti-vamp Palmitome Vamp7 Dhhc pats Tcr signaling In vitro palmitoylation T-cell activation Dhhc18 
ProteomicsHLA-DM-mediated HLA-DR3 Immunopeptidome
T2 cells stably expressing HLA-DR3 and variable amounts of HLA-DM (none, low, and high, per GFP co-expression) were lysed and HLA-DR3-peptide complexes were isolated via immunoprecipitation. Antigenic peptides were then eluted and quantified by LC-MS/MS to assess presented antigenic epitopes.
ORGANISM(S): Homo sapiens (Human) 
2018-04-16 | PXD008775 | Pride
Hla-dr Hla-dm Immunopeptidome 
ProteomicsHLA-DM allotypes - Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation
Major Histocompatibility Complex of Class II (MHCII) antigen presentation is a key event of adaptive immunity. HLA-DM favors the presentation of kinetically stable peptide-MHCII complexes but does not bind peptides itself and exhibits only a low degree of polymorphism. To date, no evidence for alter...
ORGANISM(S): Homo sapiens (Human) 
2018-10-31 | PXD009791 | Pride
Antigen presentation/ mhc class ii/ immunopeptidome/ peptide editing/ polymorphism 
UnknownMononuclear cell secretome protects from experimental autoimmune myocarditis.
Not available
S-EPMC4359357 | biostudies-literature
UnknownThe ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth.
Not available
S-EPMC5239461 | biostudies-literature
UnknownDickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.
Not available
S-EPMC7683080 | biostudies-literature
UnknownDiscovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.
Not available
S-EPMC6880298 | biostudies-literature
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