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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
ProteomicsTandem affinity purification for sigma3 interacting host proteins
In order study the mechanism of how sigma3 regulates NF-kB activation, we performed tandem affinity purification to identify its host interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061062 | Pride
Tandem affinity purification Reovirus Ms 
ProteomicsDimethyl fumarate targets in macrophages
To understand the molecular mechanism underlying DMF’s inhibition of NLRP3 inflammasome in macrophage, we conducted chemoproteomics to identify the specific protein targets of DMF. We used MMFyne, a previously reported clickable DMF analogue to label and help identify potential DMF target proteins i...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD063777 | Pride
Macrophage Dimethyl fumarate 
ProteomicsArgonaute proteins regulate the timing of the spermatogenic transcriptional program
Argonaute proteins are best known for their role in microRNA-mediated post-transcriptional gene silencing. Here, we show that AGO3, but not AGO2, localizes to the sex chromatin of pachytene spermatocytes nuclei, where together with AGO4, it is required for full transcriptional silencing of XY-linked...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-22 | PXD059391 | Pride
Meiosis Aargonaute Non-coding rna Brg1 Meiotic sex chromosome inactivation Sex body Spermiogenesis 
ProteomicsIntracellular proteins adsorbed on AuNPs during transcytosis and exocytosis
we set protein corona as the research object in this study, and focused on exploring the biological effects of intracellular protein corona (IPC) that formed on particle surface after transcytosis of nanomedicines. Considering the multi-functionalization characteristic, gold nanoparticles (AuNPs) we...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD015651 | Pride
Transcytosis Exocytosis Protein corona Caco-2 Aunps 
UnknownThe application of Tong-fu therapeutic method on ulcerative colitis: A systematic review and meta-analysis for efficacy and safety of rhubarb-based therapy
Not available
S-EPMC9634183 | biostudies-literature
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
MetabolomicsMetabolomic profiling of Campylobacter jejuni with resistance gene ermB by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry and tandem quadrupole mass spectrometry
The metabolome changes of Campylobacter jejuni with resistant gene ermB remain unclear. Here, we described an untargeted metabolomic workflow based on ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to investigate the metabolites perturbations mediated by erm...
2018-08-07 | MTBLS496 | MetaboLights
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
UnknownHOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4.
Not available
S-EPMC8175971 | biostudies-literature
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