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ProteomicsTimed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.
Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neov...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052730 | Pride
Retinopathy of prematurity Steroid Oxygen-induced retinopathy Dexamethasone Eye drop 
ProteomicsMitochondrial control of hypoxia-induced pathological retinal angiogenesis
Objective: Pathological retinal angiogenesis is vision threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss and with hypoxia-induced neovascularization (NV), and test interventions to address ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051410 | Pride
Lc-msms Retinal angiogenesis Neovascularization Mitochondrial respiration Hypoxia Retina Oxygen-induced retinopathy 
ProteomicsSerine supplementation suppresses hypoxia-induced pathological retinal angiogenesis
Pathological retinal angiogenesis with irregular and fragile vessels (also termed as neovascularization, a response to hypoxia and dysmetabolism) is a leading cause of vision loss in all age groups driven in part by unmet metabolic demand from retinal neurons. Sustaining neural retinal metabolism wi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056490 | Pride
Retinopathy of prematurity Serine Neovascularization Angiogenesis Retina 
ProteomicsLabel-free LC-MSMS proteomics for P30 Acox1 WT vs KO
Background: Dyslipidemia is a significant contributor to many eye diseases and the lipid processing pathways are not well understood. Peroxisomes oxidize very long-chain, monocarboxylic and dicarboxylic fatty acids. Genetic mutations in peroxisomal proteins may lead to severe neural retinal degenera...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD055240 | Pride
Lc-msms Retinas Peroxisome Acox1 
ProteomicsCombined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice
Introduction: Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with n-3 docosahexaenoic acid (DHA) alone has mixed results to prevent ROP, combined supplementati...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD061307 | Pride
Retinopathy of prematurity Dha Retinal vasculature Postnatal hyperglycemia 
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