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ProteomicsInhibition of Acyl-CoA Synthetase Long Chain (ACSL) Isozymes Decreases Multiple Myeloma Cell Proliferation, Mitochondrial Function and Affects Key Survival Pathways
Multiple myeloma (MM) is an incurable cancer of plasma cells that will cause ~12,590 deaths in the USA in 2023. Dysregulation of fatty acid (FA) metabolism is associated with MM development and progression but the underlying mechanisms remain unknown. The acyl-CoA synthetase long-chain family member...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD049304 | Pride
Triacsin c Acsl Multiple myeloma Mm.1s Acyl-coa synthetase long chain Fatty acid metabolism 
ProteomicsDevelopmet and Characterization of Three Cell Culture Ststems to Investigate the Relationship Between Primary Bone Marrow Adipocytes and Myeloma Cells
The unique properties of the bone marrow allow for migration and proliferation of multipl myeloma (MM) cells, while also providing the perfect environment for development of quiescent, drug-resistant MM cell clones. Bone marrow adipocytes (BMAds), which have recently been identified as important con...
ORGANISM(S): Homo sapiens (Human) 
2023-01-04 | PXD032753 | Pride
3d Tissue engineering Adipocytes Silk scaffolds Myeloma Bone marrow adipose 
ProteomicsExtracellular Vesicle Proteomics in Substance Use Disorder
This study investigates the proteomic composition of extracellular vesicles (EVs) derived from postmortem prefrontal cortex brain tissues of individuals with substance use disorder (SUD) and matched controls.
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD061471 | Pride
Mass spectrometry  proteomics  lipidomics  substance use disorder  vessicles 
ProteomicsFatty Acid Binding Protein 5 is a Novel Target in Multiple Myeloma
To identify protein changes in human myeloma cancer cells resulting from FABP inhibition, we treated GFP+/Luc+MM.1S cells with the single inhibitors (50 µM BMS309405 or 50 µM SBFI-26) or the combination (50 µM of each) for 48 hour, isolated total cell proteins, and performed a mass spectrometry-base...
ORGANISM(S): Homo sapiens (Human) 
2023-01-12 | PXD032829 | Pride
Rnaseq Fatty acid binding protein Fabp5 Fabp Myeloma 
ProteomicsLC-MS/MS of thoracic aorta and perivascular adipose tissue following short-term dietary methionine restriction
We are exploring pathways influenced by short-term dietary methionine restriction (MR) in thoracic aorta and associated perivascular adipose tissue (PVAT) from obese C57BL/6J male mice around 26 weeks of age. Mice were fed 60% high fat diet (HFD) until they were obese, experimental mice were given 6...
ORGANISM(S): Arachis hypogaea (Peanut) 
2025-04-07 | PXD051504 | Pride
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ProteomicsAltered Metabolomics and Inflammatory Transcriptomics in Human Bone Marrow Adipocytes After Acute High Calorie Diet and Acute Fasting
Investigated bone marrow metabolism in response to acute overnutrition (high calorie diet) and calorie deprivation (fasting). Bone marrow serum and peripheral serum were collected before and after each dietary intervention. Using proteomics analyses of the sera, we characterized nutritional influenc...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD063552 | Pride
Human  acute high calorie diet  acute fasting  bone marrow serum  peripheral blood serum  proteomics  mass spectrometry 
ProteomicsHuman PVAT and SubQ whole adipose from CABG and VR patients
Perivascular adipose (PVAT and subcutaneous adipose tissue (SubQ) from donors undergoing mitral valve repair/replacement (VR) and coronary artery bypass graft (CABG) surgeries were analyzed. There are 3 SWATH data sets. The first contains CABP PVAT, CABG SubQ, VR PVAT, and VR SubQ. The second includ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051676 | Pride
Human Cardiovascular disease Obesity Swath Adipose Diabetes 
ProteomicsCapture of candidate calpain5 interacting proteins from lysates of the human neuroblastoma SH-SY5Y cell line with analysis of LC-MSMS data using SWATH
Calpain5 (CAPN5) is a nonclassical calpain in that it lacks a pentaEF hand domain. Although widely expressed dominantly inherited mutations of CAPN5 display phenotypes primarily localized to the eye. These experiments aimed to identify proteins from the neuroblastoma cell line SH-SY5Y that may inter...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD071887 | Pride
Sh-sy5y cell line Lc-msms Catalytic domain Swath Human Calpain5 
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
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