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MetabolomicsSingle-cell and bulk level metabolomic study of the glycolysis inhibition by 2-deoxy-D-glucose in Saccharomyces cerevisiae
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In a study of the metabolic response of a clonal Saccharomyces cerevisiae population challenged by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG), this variability is shown ...
2013-05-22 | MTBLS29 | MetaboLights
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
ProteomicsUBQLN4, a regulator of protein dynamics at sites of DNA damage, is lost in a new genome instability syndrome and elevated in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis, but the mechanistic aspects of its involvement in the DNA damage response (DDR) remain largely elusive. Here, we identify a homozygous truncation mutation in the UBQLN4 gene in families with highly pleiotropic autoso...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD008299 | Pride
Dna damage Lc-ms Proteomics Ubqln4 
ProteomicsA systematic multi-omics investigation of breast cancer metabolism mapping its tiered regulation
Altered metabolism is a hallmark of cancer, but little is still known about its regulation. Here we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer cell-line across three different conditions. Integrating these multiomics data within a genome scale human me...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD006449 | Pride
Phosphoproteomics Breast cancer Proteomics Metabolomics Metabolic modeling 
UnknownBilateral Geiger mode avalanche in InSe Schottky photodiodes.
Not available
S-EPMC12375121 | biostudies-literature
UnknownPlant glucose transporter structure and function.
Not available
S-EPMC8298354 | biostudies-literature
ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
ProteomicsNovel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation
Monitoring protein synthesis is essential to our understanding of gene expression regulation, as protein abundance is thought to be predominantly controlled at the level of translation. Mass-spectrometric and RNA sequencing methods have been recently developed for investigating mRNA translation at a...
ORGANISM(S): Homo sapiens (Human) 
2019-02-18 | PXD012727 | Pride
Translatome Ribosome Punch-p 
ProteomicsProteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues
Repetitive sequences are hotspots of evolution at multiple levels. However, due to technical difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD012574 | Pride
Tumor evolution Repeat-instability Proteomic signatures 
ProteomicsProteomic landscape of multi-layered breast cancer internal tumor heterogeneity
Breast cancer often presents with a high degree of intratumor heterogeneity, resulting in therapy resistance and tumor relapse. Here, we investigated spatial intratumor heterogeneity by integrating histopathological analyses and mass spectrometry-based proteomics. Using multilayered heterogeneity sc...
ORGANISM(S): Homo sapiens (Human) 
2025-08-10 | PXD024190 | Pride
Breast cancer Proteomics Intratumor heterogeneity Mass spectrometry 
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