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ProteomicsUnveiling the mechanism of action of nature-inspired anti-cancer compounds using a multi-Omics approach
MCF-7 breast cancer cells were treated with two novel anti-cancer compounds, SIMR_3058 and SIMR_3066, and the metabolome and proteome analysed by LC-MS/MS using a timsTOF.
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD033257 | Pride
Anti-cancer Lc-msms Timstof Human Cells 
ProteomicsProteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin
Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2017-03-15 | PXD004197 | Pride
Mycobacterium smegmatis tuberculosis drug resistance sub-lethal sub-mic 
ProteomicsProteomic and Metabolomic Profiling of Invasive Methicillin Resistant Staphy-lococcus aureus : Uncovering Key Biomarkers and Pathogenic Pathways
Understanding the behavioural differences between methicillin-resistant Staphylococcus aureus (MRSA) associated with invasive versus non-invasive infections is key to unraveling their infection mechanisms and identifying biomarkers with potential translational value. This study aimed to compare the ...
ORGANISM(S): Staphylococcus aureus 
2026-06-08 | PXD071424 | Pride
Mrsa staphylococcus aureus proteomics metabolomics 
ProteomicsSalivary Proteome Alterations in Medwakh Smokers Associated with Pathogenic Pathways: Implications for Youth Health
Medwakh smoking has radically expanded among the youth in the Middle East and around the world. The rising popularity of medwakh/dokha usage is linked to the onset of several chronic illnesses including cardiovascular diseases and cancers. The present study aims to elucidate changes in the salivary ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045901 | Pride
Medwakh Human Saliva Smoking Youth 
ProteomicsMass spectroscopy-based proteomics and metabolomics analysis of BT- 474 breast cancer cells treated with Tamoxifen and/or Trastuzumab
`Triple positive` BT-474 breast cancer cells were treated with anti-cancer compounds, Tamoxifen and Trastuzumab, and the metabolome and proteome analysed by LC-MS/MS using a timsTOF.
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD033145 | Pride
Anti-cancer Lc-msms Timstof Human Cells 
ProteomicsCell wall enrichment unveils proteomic changes in the cell wall during treatment of Mycobacterium smegmatis with sub-lethal concentrations of Rifampicin
In this study, we successfully developed two gel-free approaches to specifically look at cell wall proteins in Mycobacterium smegmatis. The cell wall was subjected to differential centrifugation, differential detergent solubilisation and phase separation to yield the genuine cell wall proteome. The ...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2019-04-09 | PXD008075 | Pride
Cell wall proteomics Mycobacteria Mass spectrometry Rifampicin Tb drugs Tb Sub lethal 
ProteomicsImpact of PPP1R1A Knockdown on the Proteomic Landscape of INS-1 Cells: A Focus on Significant Modulated Pathways
PPP1R1A, or protein phosphatase 1 regulatory inhibitor subunit 1A, is an essential regulatory protein that plays a pivotal role in various cellular processes, including metabolism, cell division, and signal transduction. This protein primarily functions as an inhibitor of protein phosphatase 1 (PP1)...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-12-11 | PXD069033 | Pride
Ins-1 cells Ppp1r1a Insulin secretion Type 2 diabetes Phosphorylation 
ProteomicsProteomic Time-Course Investigation into the Effects of Exposure of Mycobacterium smegmatis to Sub-Lethal Dose of Rifampicin
Drug susceptible Mycobacterium smegmatis (Mc2-155) was exposed to a sub-MIC concentration of antimycobacterial drug Rifampicin (treated) or DMSO (control). Cells were harvested at 30, 255 and 300 minutes post-exposure and the proteome at each time analysed using LC-MS/MS on a Thermo Q-Exactive.
ORGANISM(S): Mycobacterium Smegmatis Str. Mc2 155 (ncbitaxon:246196) 
2019-03-18 | MSV000083589 | MassIVE
ProteomicsComparison of Cell Wall Proteomics of Drug Resistant M. smegmatis with and without Sub-inhibitory Rifampicin Exposure
We previously showed sub-lethal exposure to the front-line anti-TB drug rifampicin resulted in substantial adaptive remodelling of the proteome of the model organism M. smegmatis in the drug sensitive mc2155 strain (WT). Here we investigate whether these responses are conserved in an engineered, iso...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2021-11-03 | PXD027848 | Pride
Abc transporters Rifampicin Proteomics Mass spectrometry Mycobacterium smegmatis Phenotypic adaption 
ProteomicsComparison of Cell Wall Proteomics of Drug Resistant M. smegmatis with and without Sub-inhibitory Rifampicin Exposure
We previously showed sub-lethal exposure to the front-line anti-TB drug rifampicin resulted in substantial adaptive remodelling of the proteome of the model organism M. smegmatis in the drug sensitive mc2155 strain (WT). Here we investigate whether these responses are conserved in an engineered, iso...
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2021-11-02 | PXD027855 | Pride
Abc transporters Rifampicin Proteomics Mass spectrometry Mycobacterium smegmatis Phenotypic adaption 
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