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OtherAnalysis of disease-associated protein expression using quantitative proteomics - Fibulin-5 is expressed in association with hepatic fibrosis.
Data from ProteomeXchange, PXD ID: PXD001474. File: OEI6412.mzml. Published as part of J Proteome Res. 2015 Mar 25 . From the Abstract: {{i}} In order to develop non-invasive diagnostic assays for the assessment of liver fibrosis it is urgently necessary to identify molecules which are robustly exp...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014466 | GPMDB
Resource Reanalysis 
ProteomicsPatient-derived anti-Siglec-6 antibodies engineered into T cell-recruiting bispecific antibody formats for treating leukemia
Despite numerous therapeutic options, safe and curative therapy is out of reach for most chronic lymphocytic leukemia (CLL) patients. We previously reported the identification of a patient-derived CLL-binding antibody, JML-1, and identified Siglec-6 as the target of JML-1. Siglec-6 is an attractive ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD029601 | Pride
Siglec-6 Antibody Hdx-ms 
ProteomicsIdentification of novel CSF biomarkers in GRN-associated frontotemporal dementia by proteomics
Frontotemporal dementia is the second most common form of presenile dementia and autosomal dominant inheritance is present in 20-30% of cases, with mutations in granulin (GRN) as a major cause. The exact pathophysiological mechanism by which GRN mutations lead to neurodegeneration is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD012178 | Pride
Proteomics Mass spectrometry Frontotemporal dementia Biomarkers Progranulin 
ProteomicsIdentification of novel CSF biomarkers in GRN-associated frontotemporal dementia by proteomics
Frontotemporal dementia is the second most common form of presenile dementia and autosomal dominant inheritance is present in 20-30% of cases, with mutations in granulin (GRN) as a major cause. The exact pathophysiological mechanism by which GRN mutations lead to neurodegeneration is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2019-04-29 | PXD012179 | Pride
Proteomics Prm Mass spectrometry Frontotemporal dementia Biomarkers Progranulin 
ProteomicsNeurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Validation
The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD031022 | Pride
Proteomics Proteins Mass spectrometry Cerebrospinal fluid Multiple sclerosis Pediatrics 
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
ProteomicsCharacterization of the Protein Phosphatase 1 Interactome during Human Cytomegalovirus Infection
Human cytomegalovirus (HCMV) is known to incorporate protein phosphatase 1 (PP1) into its tegument, suggesting a potential role in the viral life cycle. This research project aims to characterize the interactome of PP1 during HCMV infection. Our approach combines co-immunoprecipitation and mass spec...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2024-12-21 | PXD046946 | Pride
Hcmv Cytomegalovirus Cmv Protein phosphatase 1 Pp1 
TranscriptomicsRNA-seq of human primary epithelial nasal cells infected with SARS-CoV-2 (20A clade) and treated with long chain inorganic polyphosphates (polyP120) against vehicle-(saline solution)- treated controls
Primary human nasal epithelial cells collected by nasal brushing of healthy donors (data deposited at: EVA- EMBL-EBI; project ID: PRJEB42411; analyses: ERZ1700617) were plated (3x105 cells) and infected with SARS-CoV-2 viral particles 20A (EPI_ISL_514432-S66; MOI, 0.03). After 24 hours, the infected...
ORGANISM(S): Homo sapiens 
2024-05-31 | E-MTAB-13363 | biostudies-arrayexpress
ProteomicsProteomics analysis of tumor antigens in allogenic tumor cell lysate and pancreatic tumor tissue.
Deep-proteome profiling of allogenic cell lysates and pancreatic ductal adenocarcinoma (PDAC) tissue sample with the aim to detect relevant tumor antigens (as described in Cheever et al. 2009, and directly linked to Lau et al., 2022).
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD032800 | Pride
Human Mudpit Tumor antigens 
ProteomicsAutologous Dendritic Cells Loaded with Allogenic Tumor Lysate for Surgically Resected Pancreatic Cancer Patients. Rationale and Clinical Results of a Phase II Study (REACtiVe Trial)
Determination of shared antigens in Pancreatic ductal adenocarcinoma (PDAC) tumor lysate and the allogeneic tumor drug product. The list of tumor antigenes was thereby dervied from preceeding RNA and literature research (e.g. [Cheevers et al 2009](https://europepmc.org/article/MED/19723653)).
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD025210 | Pride
Dendritic cells Immunotherapy T cells Pancreatic adenocarcinoma 
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