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ProteomicsPNET1 is an on-demand component of the nuclear pore complex gating cell proliferation rates
The nuclear pore complex (NPC) is a cornerstone of eukaryotic cell functionality, orchestrating the nucleocytoplasmic shuttling of macromolecules. Here, we report that PNET1, a transmembrane nucleoporin conserved between humans and plants, is a dynamic, adaptable NPC component, exclusively expressed...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-03-10 | PXD054475 | Pride
Arabidopsis thaliana Callus Nuclear pore complex 
GenomicsGenome-wide mapping of Nr5a2 in mouse embryonic stem cells
Nr5a2 (also known as liver receptor homolog-1, Lrh-1) has been shown to bind both the proximal enhancer and proximal promoter regions of Pou5f1 and regulate Pou5f1 in the epiblast stage of mouse embryonic development (Gu et al., 2005). Nr5a2-null embryos display a loss of Oct4 expression in the epib...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19019 | biostudies-arrayexpress
UnknownGlobal dataset of species-specific inland recreational fisheries harvest for consumption.
Not available
S-EPMC9365780 | biostudies-literature
UnknownTuning Chemical Interface Damping: Competition between Surface Damping Pathways in Amalgamated Gold Nanorods Coated with Mesoporous Silica Shells.
Not available
S-EPMC10685437 | biostudies-literature
MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific SREBP1 knockdown mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13696 | MetaboLights
MetabolomicsCaridac untargeted lipidomics in Sham or TAC-operated mice pretreated with AAV9-NC or AAV9-cTnT-shSlc9a3

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13701 | MetaboLights
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040477 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
ProteomicsTargeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
Here, we identify the USP2 (ubiquitin specific peptidase 2)-VPRBP (viral protein R binding protein) axis as a new pathway for p53 regulation. Like Mdm2 (Mouse double minute 2), VPRBP is a potent repressor of p53 but VPRBP stability is controlled by USP2. Interestingly, the USP2-VPRBP axis is also i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD040473 | Pride
Pd-1 Irf1 Usp2 inhibitors Usp2 Vprbp Pd-l1 Mdm2 and tumor suppressor P53 
TranscriptomicsHigh resolution view of bacteriophage lambda gene expression by ribosome profiling
Bacteriophage lambda is one of the most extensively studied organisms, and has been a primary model for understanding basic modes of genetic regulation. Here we examine the progress of lambda gene expression during phage development by ribosome profiling, and thereby provide a very high resolution ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-07-01 | E-GEOD-47509 | biostudies-arrayexpress
UnknownChanges in Phytochemical Compositions and Biological Activities After Fermentation According to the Harvest Periods of Mountain-Cultivated Ginseng Sprouts
Not available
S-EPMC12939806 | biostudies-literature
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