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ProteomicsLC-MS/MS interactomics analysis of Praf2 with timsTOF Pro
LC-MS/MS interactomics analysis of Praf2 using TurboID with timsTOF Pro.
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD029019 | Pride
Turboid Interactomics Praf2 Timstof pro Lc-ms/ms 
ProteomicsExtracellular vesicles derived from MPSIII microglia cell model impair neurite growth
Microglia is emerging as a key player in the progression of neurodegenerative diseases. In pediatric neurodegenerative diseases like mucopolysaccharidosis type III (MPSIII), the progressive accumulation of abnormal glycosaminoglycans (GAGs) induces a severe neuroinflammation by triggering a microgli...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050768 | Pride
Gag Evs Microglia cells Mpsiii Mouse Timstof pro2 Lc-ms/ms 
ProteomicsLC-MS/MS proteomics analysis of neuronal cells and secretomes with timsTOF Pro
The neuropeptide VGF was recently proposed as a neurodegeneration biomarker. The Parkinson's disease-related protein leucine-rich repeat kinase 2 (LRRK2) regulates endolysosomal dynamics, a process that involves SNARE-mediated membrane fusion and could regulate secretion. Here we investigate potenti...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-31 | PXD028321 | Pride
Vamps Parkinson’s disease Secretome Neuronal cells Timstof pro Lc-ms/ms 
ProteomicsBLI-MS: combining Biolayer Interferometry and Mass Spectrometry
Biolayer Interferometry (BLI) is a technology which allows to study the affinity between two interacting macro-molecules and to visualize their kinetic of interaction in real time. In this work we combine BLI interaction measurement with mass spectrometry in order to identify the proteins interactin...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-20 | PXD019440 | Pride
Biolayer interferometry  mass spectrometry  molecular interaction 
ProteomicsCystinosin turnover - Impact of cystinosin glycosylation on protein stability by differential dynamic SILAC
Cystinosis is a rare autosomal recessive lysosomal storage disorder, characterized by an intra-Cystinosis is a rare autosomal recessive lysosomal storage disorder, characterized by an intra-lysosomal accumulation of cystine. The causative gene for cystinosis is CTNS, which encodes the protein cystin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-01-16 | PXD005357 | Pride
Cystinosis Er retention Dynamic silac Turnover Cystinosin 
ProteomicsPhosphoproteomic analysis of Francisella
Francisella possesses a non-canonical T6SS that is essential for efficient phagosomal escape and access to the cytosol of infected macrophages. Using a global and site-specific phosphoproteomic analysis of Francisella we identified here a unique phosphorylation site on IglB, the TssC homologue and a...
ORGANISM(S): Escherichia coli 
2019-10-10 | PXD013619 | Pride
Phosphorylation Type vi secretion system Francisella 
ProteomicsPhosphorylation Francisella
Francisella possesses a non-canonical T6SS that is essential for efficient phagosomal escape and access to the cytosol of infected macrophages. Using a global and site-specific phosphoproteomic analysis of Francisella we identified here a unique phosphorylation site on IglB, the TssC homologue and a...
ORGANISM(S): Escherichia coli 
2023-12-20 | PXD012507 | Pride
Phosphorylation Type vi secretion system Francisella 
ProteomicsStk38 interactomics by proximity ligation
STK38 (aka NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity labelling assay, we discovered that STK38 modulates its interaction with more than 250 proteins depending on the context. Upon starvation-in...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011968 | Pride
Xpo1 Stk38 Apex 
ProteomicsDeltaFBA shotgun Francicella - The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
Fructose-1,6-bisphosphate aldolase, a ubiquitous metabolic enzyme with regulatory functions in pathogenic Francisella
ORGANISM(S): Escherichia coli 
2018-11-22 | PXD006908 | Pride
Francisella 
ProteomicsProteomic analysis of human neuronal SH-SY5Y in neurological diseases exposed to phtalates and metaks
This study aimed to reveal biological pathways involved in neurodevelopmental disorders after co-exposure to phthalates and metals by using a multi-omics analysis in a human neuronal cell line, SH-SY5Y. Mixtures of phthalates (DEHP, DiNP, BBzP) and metals (lead, methylmercury, total mercury, cadmium...
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD033091 | Pride
Neuron High ph fractionation Brain Exposome Pathway analysis 
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