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ProteomicsLC-MS/MS interactomics analysis of Praf2 with timsTOF Pro
LC-MS/MS interactomics analysis of Praf2 using TurboID with timsTOF Pro.
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD029019 | Pride
Turboid Interactomics Praf2 Timstof pro Lc-ms/ms 
ProteomicsExtracellular vesicles derived from MPSIII microglia cell model impair neurite growth
Microglia is emerging as a key player in the progression of neurodegenerative diseases. In pediatric neurodegenerative diseases like mucopolysaccharidosis type III (MPSIII), the progressive accumulation of abnormal glycosaminoglycans (GAGs) induces a severe neuroinflammation by triggering a microgli...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD050768 | Pride
Gag Evs Microglia cells Mpsiii Mouse Timstof pro2 Lc-ms/ms 
ProteomicsPhosphorylation of Rif1 by Plk1
Polo-like kinase 1 (Plk1) is an important protein kinase for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is present in S phase, little is known about its localization and function during unperturbed DNA replication. Here used recombinan...
ORGANISM(S): Xenopus tropicalis x Xenopus laevis 
2021-08-26 | PXD022410 | Pride
Xenopus Dna replication 
ProteomicsLC-MS/MS proteomics analysis of neuronal cells and secretomes with timsTOF Pro
The neuropeptide VGF was recently proposed as a neurodegeneration biomarker. The Parkinson's disease-related protein leucine-rich repeat kinase 2 (LRRK2) regulates endolysosomal dynamics, a process that involves SNARE-mediated membrane fusion and could regulate secretion. Here we investigate potenti...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-31 | PXD028321 | Pride
Vamps Parkinson’s disease Secretome Neuronal cells Timstof pro Lc-ms/ms 
ProteomicsTur1 regulates alternative TSS usage in Cryptococcus
Cryptococcus neoformans is a life-threatening basidiomycete fungal pathogen responsible for meningoencephalitis in immunocompromised patients. This yeast can adapt to diverse habitats, efficiently produces virulence factors, and escapes immune surveillance. This implies intricate mechanisms underlyi...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) Cryptococcus neoformans var. neoformans JEC21 
2024-07-03 | PXD045272 | Pride
Mass spectrometry N-terminomics Cryptococcus 
ProteomicsThe non-radioactive SUnSET assay to measure glucose-induced protein synthesis in human β-cells
Glucose regulates the expression of a limited number of genes in human pancreatic β-cells at the transcriptional level. Here, we asked whether glucose intervenes at post-transcriptional steps and regulates protein translation in human β-cell lines. First, we showed the involvement of the m-TOR pathw...
ORGANISM(S): Homo sapiens (Human) 
2021-07-27 | PXD023996 | Pride
Glucose regulation M-tor pathway Sunset Puromycin 
ProteomicsBLI-MS: combining Biolayer Interferometry and Mass Spectrometry
Biolayer Interferometry (BLI) is a technology which allows to study the affinity between two interacting macro-molecules and to visualize their kinetic of interaction in real time. In this work we combine BLI interaction measurement with mass spectrometry in order to identify the proteins interactin...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-20 | PXD019440 | Pride
Biolayer interferometry  mass spectrometry  molecular interaction 
ProteomicsPhosphoproteomic analysis of Francisella
Francisella possesses a non-canonical T6SS that is essential for efficient phagosomal escape and access to the cytosol of infected macrophages. Using a global and site-specific phosphoproteomic analysis of Francisella we identified here a unique phosphorylation site on IglB, the TssC homologue and a...
ORGANISM(S): Escherichia coli 
2019-10-10 | PXD013619 | Pride
Phosphorylation Type vi secretion system Francisella 
ProteomicsCystinosin turnover - Impact of cystinosin glycosylation on protein stability by differential dynamic SILAC
Cystinosis is a rare autosomal recessive lysosomal storage disorder, characterized by an intra-Cystinosis is a rare autosomal recessive lysosomal storage disorder, characterized by an intra-lysosomal accumulation of cystine. The causative gene for cystinosis is CTNS, which encodes the protein cystin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2017-01-16 | PXD005357 | Pride
Cystinosis Er retention Dynamic silac Turnover Cystinosin 
ProteomicsPhosphorylation Francisella
Francisella possesses a non-canonical T6SS that is essential for efficient phagosomal escape and access to the cytosol of infected macrophages. Using a global and site-specific phosphoproteomic analysis of Francisella we identified here a unique phosphorylation site on IglB, the TssC homologue and a...
ORGANISM(S): Escherichia coli 
2023-12-20 | PXD012507 | Pride
Phosphorylation Type vi secretion system Francisella 
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