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ProteomicsPhosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2
Abstract Primary cilia are organelles necessary for proper implementation of developmental and homeostasis processes. To initiate their assembly, coordinated actions of multiple proteins are needed. Tau tubulin kinase 2 (TTBK2) is a key player in the cilium assembly pathway, controlling final step o...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD014199 | Pride
Cep83 Cep89 Ccdc92 Mass spectrometry Phosphorylation Rabin8 Dvl3 Cep164 Ttbk2 
ProteomicsRNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer
Wnt/b-catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt-hypersensitive tumors that are susceptible to anti-Wnt-based thera...
ORGANISM(S): Homo sapiens (Human) 
2020-08-14 | PXD020478 | Pride
Porcn inhibitors Cancer mutations Rnf 43 Human colon organoids Wnt signaling Lc-ms/ms 
ProteomicsPoly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance
Poly (ADP-ribose) polymerases (PARPs) are specific enzymes catalyzing the post-translational addition of ADP-ribose moieties to proteins. In most eukaryotic cells, their primary protein targets are involved in DNA recombination, repair, and chromosome maintenance. Even though this group of enzymes i...
ORGANISM(S): Yarrowia lipolytica (Candida lipolytica) 
2025-09-15 | PXD048801 | Pride
Parp Yarrowia lipolytica Lc-ms/ms 
ProteomicsInteractome analysis of DVL3 S/T cluster mutants using proximity labeling
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Here, we mutated key serine/threonine residues in the intrin...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD067002 | Pride
Dishevelled Turboid Proximity labeling Interactome 
ProteomicsMultisite phosphorylation of intrinsically disordered region of DVL
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD063926 | Pride
Dishevelled Endogenous Phosphorylation 
ProteomicsMultisite phosphorylation of intrinsically disordered region of DVL
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD063852 | Pride
Dishevelled Phosphorylation 
ProteomicsDishevelled-3 protein conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we developed the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living...
ORGANISM(S): Homo sapiens (Human) 
2019-04-02 | PXD013085 | Pride
Dishevelled Casein kinase 1 ɛ Conformation Phosphorylation Flash-based fret approach 
ProteomicsComparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
Background: Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose phosphorylation generates complex barcodes underlying diverse DVL3 functions. ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015963 | Pride
Dishevelled/dvl3/phosphorylation/kinase/mass spectrometry/ck1/ttbk2/nek2/wnt 
ProteomicsPre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Docetaxel resistance presents a significant obstacle in the treatment of prostate cancer (PCa), resulting in unfavorable patient prognoses. Intratumoral heterogeneity, often associated with epithelial-to-mesenchymal transition (EMT), has previously emerged as a phenomenon facilitating adaptations to...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050073 | Pride
Prostate cancer Plasticity Docetaxel-resistance Ssea-4 Intratumoral heterogeneity Cd95/fas 
ProteomicsOptimization of an RNA-centric approach searching for RNA-interacting proteins in Arabidopsis thaliana
The number of methods used to study RNA-protein interactions in plants is currently relatively limited. The RNA-centric approach, starting with RNA of interest, brings several difficulties, especially when the RNA belongs to the less abundant RNAs. These methods for identification of RNA-interactin...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-22 | PXD046839 | Pride
Arabidopsis thaliana Telomerase Rna Rna-centric methods Rna-protein interactions Chirp-ms Telomerase rna Lc-ms/ms 
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