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ProteomicsHDX-MS analysis of NKp46 with next gen antibodies
Eptiopes of 7 unique antibodies produced by two complementary in vivo platforms utilizing a common light chain, in a chicken (OmniClic) or rat (OmniFlic) host species on NKp46 were analysed using HDX-MS. NKp46 was used as a model target antigen due to its use in emerging Natural Killer (NK) immune e...
ORGANISM(S): Homo sapiens (Human) 
2025-11-27 | PXD069455 | Pride
Epitope Antibody Nkp46 Hdx 
ProteomicsHDX-MS analysis of a TTC7B specific nanobody to inhibit EFR3 mediated PI4KA recruitment
Phosphatidylinositol 4 kinase III (PI4KIII/PI4KA) is an essential lipid kinase that is critical for regulating plasma membrane identity. PI4KA is primarily recruited to the plasma membrane through targeted recruitment by the proteins EFR3A and EFR3B, with these binding to the PI4KA accessory protein...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD066213 | Pride
Pi4ka Hdx-ms Nanaobody Ttc7b 
ProteomicsStructure of the phosphoinositide 3-kinase p110-p101 complex reveals molecular mechanism of GPCR activation
The class IB phosphoinositide 3-kinase (PI3K), PI3K, is a master regulator of immune cell function, and is a promising drug target for both inflammatory diseases and cancer. Critical to PI3K function is the association of the p110 catalytic subunit to either a p101 or p84 regulatory subunit, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025209 | Pride
Hdx Cryo-em Gpcr Pik3g 
ProteomicsAnalysis of mng-SHIP1-dCT with pY Peptide by HDX-MS
Hydrogen deuterium exchange mass spectrometry (HDX-MS) was used to analyze how the mng-SHIP1-dCT construct interacts receptor-derived phosphotryrosine peptides (pY) to probe how these peptides regulate SHIP1 autoinhibition. This HDX-MS helped to identify intramolecular contacts involved in the regul...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD058704 | Pride
Ship1 Hdx-ms 
ProteomicsAllosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
To provide additional insight into the molecular mechanisms underlying p110 phosphorylation we carried out hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments on p110 and phosphorylated p110 (90.8% phosphorylated S594/595, 92% phosphorylated S582. When we compared phosphorylated p110 ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-06 | PXD040765 | Pride
Pi3k Hdx-ms Phosphorylation Hdx 
UnknownFirst-line treatment selection and early monitoring patterns in chronic phase-chronic myeloid leukemia in routine clinical practice: SIMPLICITY.
Not available
S-EPMC5659133 | biostudies-literature
UnknownHaem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue.
Not available
S-EPMC12116240 | biostudies-literature
ProteomicsLabel free proteomics of the IPF Lung
Idiopathic pulmonary fibrosis is a debilitating disease leading ultimately to death without existing treatment. Here we profiled the proteome of 30 IPF cores and 10 control cores. The goal was to validate findings of snRNA-seq and new informatics means to mine the data (UNAGI) and evaluate in silico...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-16 | MSV000093129 | MassIVE
TranscriptomicsGenome-wide analysis of the genetic regulation of gene expression in human neutrophils
Here we report an expression dataset of isolated neutrophils from 114 healthy individuals of Chinese ethnicity collected in Singapore. A total of 114 individuals with no case control stratification.
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-70044 | biostudies-arrayexpress
GenomicsGlioma GWAS summary statistics DAC
Data Access Committee EGAC00001001116
EGAC00001001116 | EGA
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