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ProteomicsKinome profiling of diffuse large B-cell lymphoma cells in response to dasatinib
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, with at least one-third of its patients not responding to the current chemotherapy regimen, R-CHOP. By gene expression profiling, patients with DLBCL can be categorized into two clinically relevant subtypes: activated B-cell (ABC) DL...
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD009380 | Pride
Lymphoma Cancer Dasatinib Lc-ms Kinome 
ProteomicsDetermining kinome changes in response to Cytomegalovirus US28 expression and identifying US28 interacting proteins
Cytomegalovirus (CMV) reactivation of latent infection following immune dysregulation remains a serious risk for patients, often causing significant morbidity and mortality. Herein, we demonstrate the CMV-encoded GPCR, US28, in coordination with cellular Ephrin receptor A2 (EphA2), attenuates MAPK s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033391 | Pride
Viral infection Affinity purification-mass spectrometry Kinome 
ProteomicsLC-MS/MS of SETDB1 3TD after incubation with covalent ligands
In order to confirm which amino acid of the 3TD of SETDB1 is covalently modified by a set of cysteine-targeting ligands, we performed LC-MS/MS on sample containing 40 uM of SETDB1 3TD with 400 uM of ligand after overnight incubation at 4 C.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056206 | Pride
Setdb1 Unc9846 Unc10016 Unc10013 3td Unc10014 
ProteomicsKinome profiling upon HCMV infection using the MIB-MS approach
Human cytomegalovirus (HCMV) is a significant cause of disease in immune-compromised adults and immune naïve newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need...
ORGANISM(S): Homo sapiens (Human) 
2017-03-20 | PXD005276 | Pride
Hcmv Human herpesvirus Kinase inhibitors Kinome Antivirals Virology Label-free quantitation 
ProteomicsDetermining the KRAS-regulated kinome in PDAC
Oncogenic KRAS drives cancer growth by activating diverse signaling networks, not all of which have been fully delineated. We set out to establish a system-wide profile of the KRAS-regulated kinase signaling network (kinome) in KRAS-mutant pancreatic ductal adenocarcinoma (PDAC). We knocked down KRA...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025819 | Pride
Human Mib Pancreatic cancer Pdac Cell line Lc-ms/ms Kras 
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