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UnknownEvaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model.
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S-EPMC8130947 | biostudies-literature
ProteomicsSpheroids treated with and without Drug
MALDI MSI for monitoring of drug response in primary cancer spheroids
ORGANISM(S): Homo sapiens (Human) 
2019-09-03 | PXD013069 | Pride
Spheroids 
ProteomicsEgg White as a quality control in MALDI Mass Spectrometry Imaging
Tryptic peptides and N-glycans were spatially mapped and visualised on formalin-fixed paraffin-embedded (FFPE) endometrial cancer tissue microarrays (TMAs) using an ultrafleXtreme MALDI-ToF/ToF MS instrument (Bruker Daltonics). FFPE egg white was placed either side of each TMA and used as an externa...
ORGANISM(S): Gallus gallus (Chicken) 
2019-12-11 | PXD014310 | Pride
Maldi Ffpe Imaging Egg white 
ProteomicsIEF fractionation OVCAR-5 cell line
Analysis of the ovarian cancer cell line OVCAR-5. A standard trypsin digest was carried out on the OVCAR-5 cell lysates which were then analysed in the un-fractionated and fractionated forms. Fractionation was completed using a peptide IEF separation method. All samples were analysed by nano-LC-ESI-...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003547 | Pride
Ief fractionation lc-ms/ms ovarian cancer cell line 
ProteomicsBottle conditioning - yeast strain
LC-MS of yeast strain that maintained high viability during bottle conditioning compared to strain that had poor viability during bottle conditioning.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD053930 | Pride
Lc-ms Beer Saccharomyces cerevisiae Bottle conditioning 
ProteomicsIn-house packed porous graphitic carbon columns for liquid chromatography-mass spectrometry analysis of N-glycans
Although many reversed and normal stationary phases have been utilised for the separation of N-glycans, porous graphitic carbon (PGC) chromatography has become desirable because of its higher resolving capability, but is difficult to implement in a robust and reproducible manner. Herein, we demonstr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-07-08 | PXD024489 | Pride
Hypercarb Mass spectrometry Pgc Liquid chromatography N-glycan Porous graphitic carbon Lcmsn-glycan 
ProteomicsT cell activation decreases microRNA-15a/16 levels as a mechanism to promote MEK1-ERK1/2-Elk1 signaling for optimal proliferative capacity
While microRNAs (miRs) have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T cell activation are less clear. We found reduced levels of miR-15a/16 at 3-18 h post-T cell receptor (TCR) stimulation, suggesting a role in shaping T cell activat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD030935 | Pride
Microrna (mirna) Cell signaling Mitogen‐activated protein kinase (mapk) Cell growth Cell cycle 
ProteomicsAltered N-linked Glycosylation in Endometrial Cancer
It has been recognised for a long time that cell surface glycans plays a vital role in the biological process and their altered form can lead to cancer. However, the molecular details and regulatory mechanism between the glycans and cancer is yet not clear. Over the past decade mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2020-11-27 | PXD019425 | Pride
Biomarker Lymph node metastasis Endometrial cancer Glycan imaging 
ProteomicsDevelopment of an optimized LC-MS workflow for Host Cell Protein characterization to support upstream process development
Host cell proteins (HCPs) co-expressed during the production of biotherapeutics can affect the safety, efficacy and stability of the final product. As such, monitoring HCPs populations and amounts throughout the production and purification process are an essential part of the overall quality control...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2025-05-07 | PXD053035 | Pride
Process analytical technologies Host cell proteins Lc-ms Clarified cell culture fluid Absolute quantification Chinese hamster ovary Data-independent acquisition Hi3 quantification Bio-processing 
ProteomicsComprehensive proteomics analysis methods: Pre-Invasive Serous Lesions of the Endometrium and Fallopian Tube analyzed and compared
We present data from precancerous lesions from the endometrium and fallopian tube of a single patient. Using this complimentary approach, we gained a spatially defined representation of the molecular landscape within these tissue sections, and identified hundreds of proteins within the precancerous,...
ORGANISM(S): Homo sapiens (Human) 
2020-12-02 | PXD018538 | Pride
Lc-ms/ms Maldi msi 
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