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ProteomicsQuantitative mapping of proteome dynamics during polarization of human iPSC-derived neurons
Early neuronal development is a well-coordinated process in which neuronal stem cells differentiate into polarized neurons. This process has been well studied in classical non-human model systems, but to what extent this is recapitulated in human neurons remains unclear. To study neuronal polarizati...
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD020227 | Pride
Human neurons Differentiation Hipsc Npc 
ProteomicsAP-MS analysis of Secernin-1 (SCRN1)
Affinity purification-Mass spectrometry analysis of bioGFP-Secernin-1 in HEK293 cells and in rat brains.
ORGANISM(S): Rattus norvegicus (Rat) 
2019-08-23 | PXD014534 | Pride
Scrn-vap interactions. Vapb Vapa Scrn1 Ap-ms Secernin-1 
ProteomicsRTNs and DP1 Knockdown in neurons
Quantitative proteomics results of RTNs-KD neurons or DP1-KD neurons (DIV5). Peptides derived from Untreated neurons (UNT) were chemically labeled with TMT-126, pSuper-neurons with TMT-127, shRNAs_RTNs-neurons with TMT-128 and shRNA_DP1-neurons with TMT-131.
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-15 | PXD012264 | Pride
Cortical neurons Rtn Tmt labeling Dp1 Shrna. 
ProteomicsMS analysis of purified TRIM46, 480AnkG and 480AnkG-NN.
Mass spectrometry analysis of purified GFP-TRIM46, 480AnkG-GFP and 480AnkG-NN-GFP.
ORGANISM(S): Homo sapiens (Human) 
2019-08-30 | PXD013685 | Pride
Trim46 Purification Ankg. Ap-ms 
ProteomicsNeuronal interactome changes upon aggregation of Tau
To understand at molecular level how aggregation of Tau modulates its interactions with proteins we reveal key determinant for derailing Tau protein network. By performing quantitative AP-MS we define a new set of interactors which bind Tau upon fibril formation. These interactors contain disordered...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-30 | PXD015432 | Pride
Fibrils Tau Molecular chaperones Protein aggregation Hsp90 Protein-protein interactions 
ProteomicsKIF1A, TANC2, liprin-a2 interactomes identified by AP-MS.
The mechanisms by which motor proteins are loaded on vesicles and how cargos are captured at appropriate sites remain unclear. To better understand how KIF1A-based transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein Calmoduli...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-07-12 | PXD010080 | Pride
Ap-ms Tanc2 Liprin-a Lc-msms. Kif1a 
ProteomicsMm_cerebella_dimethyl
Mouse Cerebellum DNA-Damage 2D LC-MS/MS
ORGANISM(S): Mus Musculus 
2013-12-31 | PAe005208 | PeptideAtlas
ProteomicsTemporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons
At neuronal synapses, activation of group I metabotropic glutamate receptors (mGluR1/5) triggers a form of long-term depression (mGluR-LTD) that relies on new protein synthesis and the internalization of AMPA-type glutamate receptors. Dysregulation of these processes has been implicated in the devel...
ORGANISM(S): Rattus Norvegicus 
2020-10-27 | PXD020777 | panorama
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