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Proteomicslysosome proteomics in Niemann-Pick Type C disease model cells (CHOwt and NPC1-null cells)
Increasing evidence implicates lysosomal dysfunction in the pathogenesis of neurodegenerative diseases, including the rare inherited lysosomal storage disorders (LSDs) and the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease (AD and PD). The goal of this work was t...
ORGANISM(S): Homo sapiens (Human) 
2018-03-21 | PXD008438 | Pride
Magnetic nanoparticles lysosome enrichment Npc1-null cells Chowt cells Lysosome Lc-ms/ms 
ProteomicsProteomic analysis of cerebrospinal fluid in epileptic and healthy dogs
This study included four dog groups (group A: 10 healthy dogs, group B: 9 dogs with idiopathic epilepsy receiving antiepileptic medication-AEM, group C: 8 dogs with idiopathic epilepsy without AEM administration and group D: 7 dogs with seizures due to structural brain abnormalities). The epileptic...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2020-10-19 | PXD018893 | Pride
Proteomics Epilepsy Tmt Dogs Cerebrospinal fluid 
ProteomicsQuantitative label-based canine faecal proteomics
In small animals, diarrhoea is a regular presentation, the aetiology of which can be varied, from an isolated self-limiting event to more serious episodes requiring symptomatic and supportive treatment. Chronic diarrhoea, defined as diarrhoea lasting longer than 3 weeks, is a relatively common probl...
ORGANISM(S): Canis lupus 
2022-08-29 | PXD017454 | Pride
Faecal proteomics Dog Chronic diarrhoea Tandem mass tags 
ProteomicsSalivary proteome in canine pyometra
The aims were to explore whether saliva composition could reflect the physiopathological changes occurring in canine pyometra and to identify potential biomarkers of the disease using a high-throughput quantitative proteomic analysis. Saliva samples from six healthy (H) and six bitches with pyometra...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2020-04-27 | PXD018692 | Pride
Tmt Saliva Dog Canine pyometra 
ProteomicsSerum proteome profiling in canine chronic valve disease using TMT-based quantitative proteomics
Cardiovascular-related disorders (CVD) account for the highest mortality rates in the world, and affect the quality and the quantity of life of patients, creating an economic burden of prolonged therapeutic intervention. The aim of this study was to evaluate the serum protein profile of healthy and ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2020-05-26 | PXD017129 | Pride
Dog Tandem mass tag Chronic valve disease Serum proteomics 
ProteomicsSerum and urinary proteomes between healthy dogs and dogs with renal dysfunction in babesiosis using label-based high-resolution quantitative proteomics
The aim of the study was to analyse differences in serum and urinary proteomes between healthy dogs and dogs with renal dysfunction in babesiosis using label-based high-resolution quantitative proteomic approach. In the study 8 healthy control dogs (group H) and 22 dogs with naturally occurring babe...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-10-18 | PXD017263 | Pride
Urine Kidney dysfunction Tmt Serum Canine babesiosis Lc-ms/sm 
ProteomicsSerum proteomics in cats with cardiomyopathy and congestive heart failure
In this study, we aimed to identify novel serum biomarkers in feline primary cardiomyopathies with congestive heart failure, which can help to understand disease pathogenesis and assist the disease diagnosis, prognosis and management. The study included 15 cats diagnosed with CHF and CM, 5 cats with...
ORGANISM(S): Felis catus (Cat) (Felis silvestris catus) 
2020-07-19 | PXD017761 | Pride
Congestive heart failure Cat Cardiomyopathy Tmt-based proteomics Lc-ms/ms 
ProteomicsPlasma proteomic profiling of normal and over-conditioned dairy cows during the transition from late pregnancy to early lactation by LC-MS/MS
The objective of this study was to apply a quantitative proteomic approach to investigate changes in the plasma proteome of normal and over-conditioned dairy cows during the transition period. We used an animal model with a targeted difference in body condition score (BCS) at calving. For this, mult...
ORGANISM(S): Bos taurus (Bovine) 
2020-04-16 | PXD015958 | Pride
Tmt proteomics Body condition score Transition cows 
ProteomicsTMT-based quantitative proteomics of plasma from chicken challenged with lipopolysaccharide endotoxin
The change in the plasma proteome in chicken (Gallus gallus) challenged with lipopolysaccharide (endotoxin) derived from E. coli was determined by relative quantitation using a TMT label-based approach. This study provides insights into different factors contributing to innate immune response to exp...
ORGANISM(S): Gallus gallus (Chicken) 
2018-08-20 | PXD009399 | Pride
Tmt Lipopolysaccharide endotoxin infection Plasma Chicken Quantitative proteomics 
ProteomicsTMT-based proteomics of longissimus lumborum muscle in newly weaned piglets after dietary Spirulina inclusion and enzyme supplementation
The objective of this study was to evaluate the impact of dietary Spirulina and lysozyme supplementation over the muscle proteome of piglets during the post-weaning stage. Thirty piglets were randomly distributed among three diets: control (no microalga), SP (10% Spirulina) and SP+L (10% Spirulina +...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-05-24 | PXD024083 | Pride
Spirulina Weaned piglet Muscle proteome Tandem mass tag Cazyme 
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