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MetabolomicsMicrobial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Plant fibers in byproduct streams produced by non-harsh food processing methods represent biorepositories of diverse, naturally occurring, and physiologically active biomolecules. To demonstrate one approach for their characterization, mass spectrometry of intestinal contents from gnotobiotic mice, ...
2022-07-28 | MTBLS2331 | MetaboLights
MetabolomicsGut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice
Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show that dietary yogurt intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance and liver steatosis in a ...
2022-02-03 | MTBLS442 | MetaboLights
TranscriptomicsExpression of known and predicted genes in tissues of Tetraodon nigroviridis (pufferfish)
Expression of known and predicted genes in tissues of Tetraodon nigroviridis (pufferfish) pooled from multiple healthy individuals. Two-colour experiments with two different tissues hybridized to each array. Each tissue is arrayed in replicate with dye swaps. Tissues: Beak, Brain, Calvaria, Connecti...
ORGANISM(S): Tetraodon nigroviridis 
2010-06-19 | E-GEOD-12976 | biostudies-arrayexpress
ProteomicsSIK2 phosphorylation in response to glucagon or insulin in murine hepatocytes
The phosphorylation state of human HA-tagged-SIK2, adenovirally introduced in murine hepatocytes (C57/BL/6 strain) was analysed in unstimulated and in response to glucagon- or insulin- treated conditions. Background:- LKB1 is a master kinase that regulates metabolism and growth through AMPK and 12 o...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-08-08 | PXD001032 | Pride
Hepatic glucose production Hepatocytes Camp Crtc2 Ampk Glucagon Ampk-related kinase Lkb1 Sik2 Insulin Creb 
UnknownEffects of combination lipid therapy in type 2 diabetes mellitus.
Not available
S-EPMC2879499 | biostudies-literature
UnknownEffects of intensive blood-pressure control in type 2 diabetes mellitus.
Not available
S-EPMC4123215 | biostudies-literature
UnknownLong-term effects of intensive glucose lowering on cardiovascular outcomes.
Not available
S-EPMC4083508 | biostudies-literature
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.
Not available
S-EPMC4123233 | biostudies-literature
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Not available
S-EPMC5013254 | biostudies-literature
UnknownEffects of intensive glucose lowering in type 2 diabetes.
Not available
S-EPMC4551392 | biostudies-literature
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