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ProteomicsUSP25 is a HIF-1 regulator and a therapeutic target in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with both an extremely poor prognosis and response to conventional chemotherapy. Identifying novel biological vulnerabilities is therefore critical in the development of more effective therapies. By using patient-derived organoids and ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-19 | PXD023424 | Pride
Human Pancreas Lc-msms Cancer Mouse Affinity Deubiquitylase Biotin 
ProteomicsAnalysis of stalled ribosome-nascent chain complexes by quantitative proteomics
The cellular environment is critical for efficient protein maturation, but how proteins fold during biogenesis remains poorly understood. To understand how the cellular environment modulates folding, we studied the cotranslational chaperone-assisted folding of Escherichia coli dihydrofolate reductas...
ORGANISM(S): Escherichia coli 
2025-05-06 | PXD036784 | Pride
Protein biosynthesis Ribosome-nascent chain complexes Interactome Protein folding Lc-ms/ms 
ProteomicsMetabolism of host-derived glycolytic products by Mycobacterium tuberculosis requires five metabolic pathways
Bacterial nutrition is a key aspect of host-pathogen interaction and bacteria must adapt to use nutrients available in the host. Lipid droplets-derived fatty acids are considered the major intracellular carbon source for Mycobacterium tuberculosis (Mtb), an intracellular pathogen causing Tuberculosi...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2020-05-26 | PXD010726 | Pride
Lc-msms Mycobacterium tuberculosis Tmt Bacterial nutrition Glucose metabolism Orbitrap 
ProteomicsDesign of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s disease supporting the need to discover improved inhib...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-06-09 | PXD031338 | Pride
Lc-msms Carboyxlesterase Notum Inhibitor Wnt signalling 
ProteomicsPlasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020447 | Pride
Lc-msms Malaria Cell signalling Calcium homeostasis Protein kinase g Orbitrap Plasmodium falciparum 
ProteomicsThe CARD14E138A phosphoproteome
Psoriasis is a chronic inflammatory disease of the skin for which current treatments are only partially effective. There is therefore an urgent need to develop novel therapies with higher efficacy through a better understanding of disease aetiology. Recently, it has been demonstrated that individual...
ORGANISM(S): Homo sapiens (Human) 
2024-08-27 | PXD033009 | Pride
Carma Keratinocyte Malt1 Bcl10 Psoriasis Nf-kappab Card14 
ProteomicsThe CARD14WT/E138A interactome.
Psoriasis is a chronic inflammatory disease of the skin for which current treatments are only partially effective. There is therefore an urgent need to develop novel therapies with higher efficacy through a better understanding of disease aetiology. Recently, it has been demonstrated that individual...
ORGANISM(S): Homo sapiens (Human) 
2024-08-27 | PXD033039 | Pride
Carma Keratinocyte Malt1 Bcl10 Psoriasis Nf-kappab Card14 
TranscriptomicsTranscription profiling of human cutaneous tumors to identify gene expression patterns involved in the malignant transformation and progression of metastatic melanoma
Metastatic melanoma is a deadly disease while non-metastatic melanoma and other cutaneous tumor types are usually cured with surgical removal of the primary tumors. This study evaluated gene expresion to determine if gene expression differences existed which would allow one to identify the metastat...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-7553 | biostudies-arrayexpress
UnknownSafety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Not available
S-EPMC7723445 | biostudies-literature
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