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ProteomicsProteomic profiling of healthy and SLE isolated B-cells
B cells orchestrate the autoimmune responses in patients with systemic lupus erythematosus (SLE), but broad based B-cell directed therapies only show modest efficacy while attenuating humoral immune responses to vaccines and inducing acquired immunodeficiency. used proteomic and transcriptomic analy...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD031389 | Pride
B cells  atr  irf1  dna damage response  systemic lupus erythematosus  autoimmunity  proteomics 
ProteomicsEndogenous alpha-synuclein is essential for the transfer of pathology by exosomes, following PFF inoculation in vivo.
Alpha-Synuclein (α-Syn) association with exosomes has been extensively studied both as a physiological process but also as a means of disease transmission under pathological conditions, via an elusive mechanism. Here, we utilized the preformed fibril (PFF) mouse model, as a source of brain-derived e...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-04 | PXD036301 | Pride
Pathology transmission Exosomes Alpha-synuclein (α-syn) Spreading Parkinson’s disease Pff 
ProteomicsProteomic profiling maps the molecular pathways underlying the neuroprotective effects of the kinase inhibitor BX795 in a patient-derived model of Parkinson's disease
Disease-modifying therapies remain an important unmet need for neurodegenerative diseases, including Parkinson’s disease (PD). The aim of this study was to investigate the molecular pathways affected by the multi-kinase inhibitor BX795, which is neuroprotective in an induced pluripotent stem cell (i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD019574 | Pride
Proteomics Mrna metabolism Induced pluripotent stem cell derived neurons Bx795 P.a53t α-synuclein mutation Proteostasis Α-synuclein 
ProteomicsSelective Inhibition of MTHFD1/2 in T Cells from Patients with Rheumatoid Arthritis
Ex vivo T cell treatment Immunomagnetic negative isolation was used to obtain untouched human T cells from previously frozen PBMC samples of treatment-naïve (n=6) and MTX-IR (n=3) RA patients (Table S1). The isolated T cells were then cultured and stimulated in a 96-well round-bottom plates for susp...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD061849 | Pride
Proteomics Methotrexate Selective mthfd1/2 inhibitor T cells Rheumatoid arthritis 
ProteomicsProteomics Analysis of the Silkworm Cocoon Shell
In this study we conducted proteomics analyses of historical and contemporary Bombyx mori cocoon shells to case-study the human-driven introduction and diversification of this species in Europe. We employed LC-MS/MS analyses protocols for 81 cocoon shell samples to identify that the cocoon shell of ...
ORGANISM(S): Bombyx mori (Silk moth) 
2025-08-26 | PXD062351 | Pride
Silkworm Proteomics Metabolomics Lipidomics Cocoon Phenomics Europe. Bombyx mori Domestication 
ProteomicsChios Mastic Gum Extract Enhances Antioxidant Defense in Zebrafish
Chios mastic gum (CMG), derived from the resin of the Pistacia lentiscus has long been considered a natural remedy in the Mediterranean region. Its anti-inflammatory and an-tioxidant properties have garnered increasing attention from scientists and consumers over recent decades. While substantial ev...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-12-22 | PXD070358 | Pride
Chios mastic gum  zebrafish  proteomics  copper-zinc superoxide dismutase  thioredox-in-disulfide reductase  catalase 
ProteomicsPromyelocytic leukemia protein (PML) is a regulator of eNSC differentiation, survival and mitochondrial metabolism.
OThis study identifies the tumor suppressor PML as a regulator of embryonic neural stem cell (eNSC) homeostasis, highlighting its role in their proliferation, differentiation and metabolism. Loss of the promyelocytic leukemia (PML) protein has been previously linked to abnormal proliferation and dif...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD059100 | Pride
Stem cell Ensc Pml 
ProteomicsIntegrated omics analysis for characterization of the contribution of high fructose corn syrup to non-alcoholic fatty liver disease in obesity
High Fructose Corn Syrup (HFCS), a sweetener rich in glucose and fructose, is nowadays widely used in beverages and processed foods, and its consumption has been correlated to the emergence and progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Nevertheless, the exact molecular mechanisms by ...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-03 | PXD033612 | Pride
Non-alcoholic fatty liver disease  high fructose corn syrup  obesity  de novo lipogenesis  mitochondrial dysfunction  integrated omics 
ProteomicsComparative proteomic analysis of Pleurotus ostreatus mycelia grown in submerged fermentation under different light wavelength
Light is a key environmental factor in the growth, development, and metabolism of the edιble mushroom Pleurotus ostreatus. In this study, the effect of white, blue, green, yellow, red light, and darkness on the global protein expression profile of P. ostreatus LGAM 1123 grown in submerged cultivatio...
ORGANISM(S): Pleurotus ostreatus 
2025-10-15 | PXD065402 | Pride
Proteomics Gc-ms Light Photoreceptors Fungi Lc-ms?ms Biomolecules 
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