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ProteomicsIFITM3 BioID Interactomes in B-ALL and MCL
To determine the roles of membrane associated IFITM3 in BCR-signalling in B-cell malignancies we expressed N-terminal BirA-IFITM3-Y20E fusion or BirA-EV control in patient derived B-ALL cells (PDX2) and Jeko1 Mantle cell lymphoma (MCL) cells. Additionally to examine the role of PIP3 binding residues...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020697 | Pride
Human b-all mcl b-cells 
ProteomicsBioID of CD25 mutants in B-cell malignancies
CD25-dificient patient-derived PDX2 B-ALL cells and Jeko1 MCL cells with CRISPR-Cas9-mediated gene deletion were reconstituted with wild-type CD25 (S268) or CD25 carrying S268A mutant (A268) with C-terminal BirA (engineered biotin ligase) and selected by puromycin for 3 days. BirA expressing constru...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD035989 | Pride
Lc-msms B-all B-cell Cd25 Mcl Bioid Il2ra 
TranscriptomicsMantle Cell Lymphoma
Gene expression analyis of primary MCL including IGHV mutated and unmutated cases Gene set analysis was perfomed in MCL samples, comparing IGHV mutated cases vs. IGHV unmutated cases In total 38 MCL samples were processed with the HU133plus 2.0 microarray. Twenty four cases had a IGHV mutations and...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-36000 | biostudies-arrayexpress
TranscriptomicsMicroarray expression of B-cell Non-Hodgkins Lymphoma cases
Transcriptional profiling of major types of B-cell NHL clinical samples. While comparing all the types together, their expression was compared against reactive lymph nodes, except SMZL whose expression was compared against normal splenic cells. Keywords: disease state analysis Clinical samples; 8 re...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9327 | biostudies-arrayexpress
TranscriptomicsModulation of Navitoclax Sensitivity by Dihydroarteminisin-Mediated MCL-1 Repression
Poor prognosis BCR-ABL+ B-ALL leukemic cells are highly dependent on the expression of endogenous anti-apoptotic MCL-1. However, the survival of most normal blood cells (e.g. progenitors, lymphocytes, and granulocytes) and other normal cell types (e.g. cardiomyocytes and neurons) are also exquisitel...
ORGANISM(S): Mus musculus 
2018-02-14 | GSE95809 | GEO
TranscriptomicsTranscription profiling of human MCL1 over-expressing B-NHL cells
To get insight into the mechanisms of MCL1-induced survival and transformation, we screened 41,000 human genes in a genome-wide gene expression profile analysis of MCL1 over-expressing B-NHL cells. Experiment Overall Design: Two-color (Cy5-CTP/ Cy3-CTP) microarray-based gene expression formats prese...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8834 | biostudies-arrayexpress
UnknownCotargeting BCL-2 and MCL-1 in high-risk B-ALL.
Not available
S-EPMC7322969 | biostudies-literature
TranscriptomicsTumor biopsies from 71 untreated patients with mantle cell lymphoma
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma Keywords: lymphochip; MCL; untreated Tumor biopsies from 71 untreated patients with mantle cell lymphoma
ORGANISM(S): Homo sapiens 
2010-05-23 | E-GEOD-10793 | biostudies-arrayexpress
TranscriptomicsDirect in vivo evidence for B-cell receptor and NF-KB activation in mantle cell lymphoma: role of the lymph node microenvironment and activating mutations. [RNA-Seq]
We provide direct in vivo evidence for activation of the BCR and canonical NF-KB pathways in MCL that, in the absence of activating mutations, is dependent on the lymph node microenvironment. This finding provides a mechanistic explanation for the surprising efficacy of ibrutinib for the treatment o...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-70926 | biostudies-arrayexpress
TranscriptomicsLongitudinal scRNAseq profiling of memory B cells in mRNA vaccinated individuals post BA.1-breakthrough infection
Memory B cells play a fundamental role in host defenses against viruses. This dataset aimed at understanding the recruitment and remodeling of the memory B cell repertoire in the context of BA.1-breakthrough infection in BNT162b2 mRNA vaccinated individuals. All four donors enrolled in the study had...
ORGANISM(S): Homo sapiens 
2023-08-15 | E-MTAB-12651 | biostudies-arrayexpress
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