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ProteomicsIntrinsically Disordered Regions in Chromodomain Helicase DNA-binding (CHD) Proteins Shape Distinct Protein Interaction Networks
Metazoans employ chromodomain helicase DNA-binding (CHD) enzymes to reposition nucleosomal DNA for transcription and replication. The CHD family consists of nine distinct members (CHD1-9) that possess highly conserved chromo and ATPase domains. These domains are flanked by poorly characterised N- an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055009 | Pride
Dna helicase Chromatin remodelers Transcription Intrinsically disordered regions Aggregation prone regions Protein-protein interactions 
UnknownAnalysis of structured and intrinsically disordered regions of transmembrane proteins.
Not available
S-EPMC2887740 | biostudies-literature
UnknownForkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.
Not available
S-EPMC5314938 | biostudies-literature
ProteomicsBRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct residues on the C-terminal tail of histone H2A. These enzymatic domains const...
ORGANISM(S): Homo sapiens (Human) 
2023-06-21 | PXD035345 | Pride
Kojak Brca1 Cancer Nucleosome Cross-linking mass spectrometry Proxl H2a Xl-ms Bard1 Tumor Ubiquitin ligase 
GenomicsThe intrinsically disordered AR2 microdomain of RNase E binds mRNA translation initiation regions
The intrinsically disordered AR2 microdomain of RNase E binds mRNA translation initiation regions
PRJNA1415097 | ENA
UnknownInfluence of sequence changes and environment on intrinsically disordered proteins.
Not available
S-EPMC2727479 | biostudies-literature
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - PRM dataset-
Mutations in intrinsically disordered regions (IDRs) of proteins are associated with a wide spectrum of diseases. Since IDRs lack a fixed three-dimensional structure, the molecular mechanism by which such mutations cause disease is often unknown. Here, we employ a peptide-based proteomic screen to i...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010005 | Pride
Glut1 Disordered regions Prm Dileucin 
GenomicsIntrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
PRJNA1065311 | ENA
ProteomicsBiotin proximity tagging favors unfolded proteins and enables the study of intrinsically disordered regions
Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein regions contribute to biological functions. We reasoned that IDRs should be more access...
ORGANISM(S): Escherichia coli 
2020-01-29 | PXD016422 | Pride
Lc-sps-ms3 E. coli H. sapiens Idr Biotin 
GenomicsIntrinsically Disordered Regions Form Nucleoli and Cajal Bodies While Fostering RNA Modification
Intrinsically Disordered Regions Form Nucleoli and Cajal Bodies While Fostering RNA Modification
PRJNA1285881 | ENA
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