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ProteomicsModeling cooperative tumor suppression in the p53 target gene network with in vivo genetic screens and multi-omics
The tumor suppressor TP53 is the most frequently mutated gene in human cancer. TP53 encodes a transcriptional activator that induces numerous downstream target genes, but those genes critical for tumor suppression remain elusive. To shed light on the downstream target genes important for tumor suppr...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-17 | PXD047240 | Pride
Mouse Embryonic fibroblast P53 
ProteomicsCEP19-RABL2 GTPase complex in ciliary transport
The mechanisms of how highly conserved intraflagellar transport (IFT) protein complexes direct ciliary entry remain unknown. Exploring human ciliopathy genes, including monogenic obesity syndrome genes, has been a rich source of critical ciliary mechanisms. Using AP-MS purification of interactors of...
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD006757 | Pride
Metabolic syndrome Gtpase Cep19-rabl2b complex Microtubules Bardet-biedl syndrome Proteomics Genetics" Obesity Ciliopathy Human genetics Centrosome Intraflagellar transport Centriole Cilia 
ProteomicsPhosphoproteome of SARS-CoV-2 infected Human Nasal Epithelium
The nasal epithelium is the primary initial site of SARS-CoV-2 entry in the human body. Since much of the molecular detail defining coronavirus entry and replication was derived from non-nasal cell lines, it remains unclear how SARS-CoV-2 overcomes the physical nasal mucus and periciliary mucin laye...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028123 | Pride
Sars-cov-2 Human nasal epithelium Phosphoproteome 
ProteomicsLKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the aggressi...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-23 | PXD026738 | Pride
Lung adenocarcinoma Mouse model Lkb1 Tumor suppressor 
ProteomicsSARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Emerging evidence points towards an intricate relationship between the pandemic coronavirus disease 2019 (COVID-19) and diabetes. While diabetes is associated with an increased risk of severe COVID-19, new-onset type 1 diabetes (T1D) has been observed in COVID-19 patients, convoluting diabetes as bo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-07-24 | PXD025629 | Pride
Pancreas Beta-cells Sars-cov-2 Human 
ProteomicsMouse ciliopathy-associated CPLANE proteins
Combining proteomics, in vivo imaging and genetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified and characterized a new genetic module, which we term CPLANE (ciliogenesis and planar polarity effector), and an extensive associated protein network. CPLA...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-15 | PXD004741 | Pride
"planar cell polarity” Mouse Ciliopathy “human genetics" Cplane 
ProteomicsProtein-Protein Interactions Maps of the KRAS Pathway in HEK293 and A549 cells
Activating mutations in RAS GTPases drive one fifth of cancers, but poor understandings of many RAS effectors and regulators, and of the roles of their different paralogs, continue to impede drug development. We developed a multi-stage discovery and screening process to understand RAS function and i...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD015485 | Pride
Cancer Lung adenocarcinoma Gtpase Protein-protein interaction Ap/ms Kras 
UnknownProspective follow-up of quality of life for participants undergoing risk-reducing salpingo-oophorectomy or ovarian cancer screening in GOG-0199: An NRG Oncology/GOG study.
Not available
S-EPMC6980744 | biostudies-literature
UnknownWhite Matter Abnormalities and Cognition in Aging and Alzheimer Disease.
Not available
S-EPMC12150229 | biostudies-literature
UnknownSARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Not available
S-EPMC8723827 | biostudies-literature
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