Sort   by:  
 Page size 
UnknownSequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation.
Not available
S-EPMC8429659 | biostudies-literature
ProteomicsDeep 3T3-L1 adipocyte proteome at 10 days post-differentiation
Here we conducted a comprehensive analysis of the proteome of the widely used 3T3-L1 murine adipocyte laboratory cell line at 10-days post-differentiation.
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD039532 | Pride
Mouse Adipocytes 
ProteomicsSex-specific Phosphoproteome Responses to Calorie Restriction and Insulin in Skeletal Muscle from Older Rats
Aging impairs skeletal muscle insulin sensitivity, yet the underlying molecular mechanisms remain incompletely understood. Here, we examined how short-term caloric restriction (CR) alters muscle insulin action and signaling in aged rats (22 months old) of both sexes. After 8 weeks of CR or ad libitu...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-24 | PXD064514 | Pride
Calorie restriction Phosphoproteome Rats Skeletal muscle Muscle 
UnknownCu-NHC Complex for Chan-Evans-Lam Cross-Coupling Reactions of <i>N</i>-Heterocyclic Compounds and Arylboronic Acids.
Not available
S-EPMC12889171 | biostudies-literature
ProteomicsPhosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance
Here we employed phosphoproteomics to delineate insulin signal transduction in adipocyte cells and adipose tissue. Across a range of insults triggering insulin resistance, we observed marked rewiring of the insulin signaling network. This included both attenuated insulin-responsive phosphorylation, ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-17 | PXD032913 | Pride
Post-translational modification Adipocyte Mass spectrometry Fat Phosphoproteomics Gsk3 Tissue Proteomics Adipose Signal transduction Phosphorylation Insulin signalling Insulin resistance 
TranscriptomicsTranscription profiling of brain and spleen from rhesus macaque to validate two oligonucleotide array
We constructed a database containing 248,000 exon sequences from 23,000 human RefSeq genes and compared each human exon with its best matching sequence in the January 2005 version of the rhesus genome project list of 486,000 DNA contigs. Best matching rhesus exon sequences for each of the 23,000 hum...
ORGANISM(S): Macaca mulatta 
2007-01-10 | E-TABM-189 | biostudies-arrayexpress
ProteomicsDeep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots
The two major mammalian adipose tissue depots are subcutaneous adipose tissue (SAT), which is associated with metabolic protection, and abdominal/visceral (VAT), which contributes to metabolic disease. To investigate the molecular underpinnings of these differences, we conducted a comprehensive anal...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD039523 | Pride
Mouse Adipocytes Adipose tissue Visceral fat Subcutaneous fat 
ProteomicsAkt phosphorylates insulin receptor substrate (IRS) to limit PI3K-mediated PI(3,4,5)P3 synthesis
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. Here, we show that Akt itself engages negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Mechanistic...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-14 | PXD023441 | Pride
Irs1 Signal transduction Pi3k Phosphorylation Akt Irs2 
ProteomicsDiscovery of drugs to treat cytokine storm-induced cardiac dysfunction
SARS-CoV2 infection leads to cardiac injury and dysfunction in 20-30% of hospitalized patients and higher rates of mortality in patients with pre-existing cardiovascular disease. Inflammatory factors released as part of the 'cytokine storm' are thought to play a critical role in cardiac dysfunction ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD020994 | Pride
Sars-cov2 Cardiac organoids Cytokine storm Easyphos Phosphoproteomics Covid-19 Heart 
TranscriptomicsHigh-throughput gene expression profiling of Salmonella enterica serovar Paratyphi A in the blood of bacteremic patients in Bangladesh
In this work, we applied an RNA analysis method, Selective Capture of Transcribed Sequences (SCOTS), and cDNA hybridization-microarray technology to identify S. Paratyphi A transcripts expressed by bacteria in the blood of three patients in Bangladesh. In total, we detected 1798 S. Paratyphi A mRNA...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Paratyphi A 
2010-09-06 | E-GEOD-22958 | biostudies-arrayexpress
Sort   by:  
 Page size