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One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we performed proteomic profiling of the Cohesin in chromatin and id...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-05 | PXD028860 | Pride
The mechanisms governing the termination and subsequent reinitiation of RNA polymerase II (Pol II) remain poorly understood. Here we found that depletion of RPB7 leads to the destabilization of Pol II’s largest subunit, RPB1. This destabilization is influenced by the loop regions of RPB7, CDK9, the ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD048909 | Pride
We previously identified an interaction between the RNA polymerase II (Pol II) subunit RPB7 and the phosphatase CTDP1 in regulating transcription termination-reinitiation. Here, we establish that CTDP1 dephosphorylates a unique Pol II phospho-isoform modified at Tyr1, Ser5, and Ser7 of its C-termina...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-07-10 | PXD071392 | Pride
RUVBL2 is most important AAA+ ATPase for RNA polymerase II assembly and transcription regulation, through DNA remodeling or by directly interaction with PIC,this study will comprehensively to study the promiscuous functions of this proteins through the ChIP-MS, ChIP-seq, RNA-seq and nascent RNA seq ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD036528 | Pride
One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we performed proteomic profiling of the Cohesin in chromatin and id...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-05 | PXD036004 | Pride
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