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ProteomicsACBD6-related progressive neurodevelopmental disorder – whole proteome of developing Danio rerio (zebrafish)
In triplicate for each condition, 12 WT and acbd6 F0 crispant Danio rerio (zebrafish) embryos were incubated with 20 μM YnMyr for 24 h, either between 48-72 hpf or 96-120 hpf. After labelling, zebrafish were washed twice with fresh egg water, deyolked, flash frozen in liquid nitrogen and stored at -...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-06-16 | PXD043679 | Pride
Acbd6 Whole proteome Danio rerio 
ProteomicsACBD6-related progressive neurodevelopmental disorder – whole proteome of developing Xenopus tropicalis
In quadruplicate for each condition, 10 acbd6 WT, 68 acbd6 crispant and 71 crispant X. tropicalis embryos were incubated with 20 μM YnMyr for 17 h. After labelling, embryos were washed twice with fresh 0.05 x MMR, flash frozen in liquid nitrogen and stored at -80°C until further analysis.
ORGANISM(S): Xenopus tropicalis 
2024-06-16 | PXD043680 | Pride
Acbd6 Xenopus tropicalis Whole proteome 
ProteomicsACBD6-related progressive neurodevelopmental disorder – chemical proteomics of YnMyr-labelled proteins in developing Danio rerio (zebrafish)
In triplicate for each condition, 12 WT and acbd6 F0 crispant Danio rerio (zebrafish) embryos were incubated with 20 μM YnMyr for 24 h, either between 48-72 hpf or 96-120 hpf. After labelling, zebrafish were washed twice with fresh egg water, deyolked, flash frozen in liquid nitrogen and stored at -...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-06-16 | PXD043676 | Pride
Acbd6 Danio rerio N-myristoylation Ynmyr 
ProteomicsACBD6-related progressive neurodevelopmental disorder – chemical proteomics of YnMyr-labelled proteins in developing Xenopus tropicalis
In quadruplicate for each condition, 10 acbd6 WT, 68 acbd6 crispant and 71 crispant X. tropicalis embryos were incubated with 20 μM YnMyr for 17 h. After labelling, embryos were washed twice with fresh 0.05 x MMR, flash frozen in liquid nitrogen and stored at -80°C until further analysis.
ORGANISM(S): Xenopus tropicalis 
2024-06-16 | PXD043677 | Pride
Acbd6 Xenopus tropicalis N-myristoylation Ynmyr 
ProteomicsValidation and invalidation of chemical probes for the human N-myristoyltransferases.
On-target, cell-active chemical probes are of fundamental importance in both chemical and cell biology, whereas the application of poorly-characterised probes often leads to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as a target in cancer and infectious...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD012722 | Pride
N-myristoylation Imp-366 (ddd85646) Metabolic tagging Tris-dba palladium Myristic acid alkyne ynmyr Chemical proteomics Imp-1088 D-nmappd (b13) 2-hydroxymyristic acid 
ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - Mitochondrial fractionation
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conduced pathway-level anal...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD056941 | Pride
N-myristoyltransferase Proteomics Mitochondrial fractionation N-myristoylation 
ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - DoHH2 proteomics
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conducted pathway-level ana...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD063851 | Pride
Proteomics Myc Nmt N-myristoylation Dohh2 
ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - Th-MycN tumour proteomics
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conducted pathway-level ana...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-30 | PXD063661 | Pride
Nmt inhibitor Th-mycn Nmt N-myristoylation 
UnknownGBP1 recruitment to actin-rich pedestals of extracellular Gram-negative bacteria promotes pyroptosis
Not available
S-SCDT-10_1038-S44318-026-00830-Z | biostudies-other
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