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ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014499 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
TranscriptomicsMonitoring Homology Search during DNA Double-Strand Break Repair in vivo
Homologous recombination (HR) is crucial for genetic exchange, accurate repair of DNA double-strand breaks and pivotal for genome integrity. HR uses homologous sequences for repair, but how homology search, the exploration of the genome for homologous DNA sequences, is conducted in the nucleus remai...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-21 | E-GEOD-44844 | biostudies-arrayexpress
ProteomicsPhosphorylation site mapping on purified mGluR8/arrestin complexes
phosphorylation sites of purified mGluR8 with arrestin are mapped by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD055267 | Pride
Neuronal receptor Gpcr Phosphorylation Metabotropic glutamate receptor 8 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014501 | Pride
Isobaric labeling Isoproterenol Tmt Alkaline reversed phase peptide fractionation Non-transgenic Cardiomyocytes Quantitative mass spectrometry Sps ms3 B-adrenergic regulation 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014500 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
ProteomicsIn situ Proteomics of Brain Cilia Unveils Molecular Mechanisms of Cilia-Synapse Interactions
Neuronal cilia have emerged as pivotal signaling hubs; yet the ciliary molecules that organize signaling modalities and communication with neighboring synapses remain elusive. To map the brain cilia proteome, we engineered an Arl13b-TurboID mouse that enabled robust cilia-specific biotinylation in a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD067626 | Pride
Expansion microscopy Neuronal cilia Proximity proteomics Cilia-synapse interaction Synaptic signaling 
ProteomicsTime-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations
Transcription factors (TFs) can relay signals through temporal alterations in their levels. The cell stress responsive TF p53 exhibits different dynamics depending on the type of stress, which influence the magnitude and dynamics of expression of its target genes and subsequent cellular outcomes. Th...
ORGANISM(S): Homo sapiens (Human) 
2022-02-11 | PXD027030 | Pride
P53 targets dynamic oscillatory sustained proteomics tmt multiplex mrna rnaseq 
ProteomicsProteomic profiling of the ciliary Hedgehog response reveals coordinated exit of GPR161 and PKA
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid and second messenger compositions. Here, we combine proximity labeling of cilia with quantitative mass spectrometry to unbiasedly profile the time-dependent alterations of the ciliary...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-07 | PXD024366 | Pride
Hedgehog signaling Proteomics Proximity labeling Protein trafficking Primary cilium 
ProteomicsProteomic profiling of the ciliary Hedgehog response reveals coordinated exit of GPR161 and PKA
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid and second messenger compositions. Here, we combine proximity labeling of cilia with quantitative mass spectrometry to unbiasedly profile the time-dependent alterations of the ciliary...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-07 | PXD024361 | Pride
Hedgehog signaling Proteomics Proximity labeling Protein trafficking Primary cilium 
ProteomicsProteomic profiling of the ciliary Hedgehog response reveals coordinated exit of GPR161 and PKA
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of its protein, lipid and second messenger compositions. Here, we combine proximity labeling of cilia with quantitative mass spectrometry to unbiasedly profile the time-dependent alterations of the ciliary...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-07 | PXD024367 | Pride
Hedgehog signaling Proteomics Proximity labeling Protein trafficking Primary cilium 
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