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ProteomicsUtilisation of Galleria mellonella larvae to characterise development of Staphylococcus aureus infection
Staphylococcus aureus is a common human opportunistic pathogen which causes a wide range of infections from superficial skin infections to invasive infections including pneumonia and bloodstream infections. Here we describe how an inoculum of S. aureus activates the cellular and humoral response of ...
ORGANISM(S): Galleria mellonella 
2019-05-21 | PXD012766 | Pride
Infection Immunity Staphylococcus : galleria Mini-model 
ProteomicsInvestigating the transition of Apis mellifera summer workers to diutinus workers using proteomic techniques.
Apis mellifera workers in temperate climates display two castes; short lived summer bees that engage in nursing, hive maintenance and foraging, and long lived winter bees (diutinus bees) which remain within the hive and are essential for thermoregulation. Label free quantitative proteomic analysis ...
ORGANISM(S): Apis mellifera (Honeybee) 
2022-11-21 | PXD032755 | Pride
Apis mellifera  seasonal adaptations  proteomic comparison  longevity 
ProteomicsProteomic comparison of summer and winter Apis mellifera workers shows reduced protein abundance in winter samples
Apis mellifera workers in temperate climates display two castes; short lived summer bees that engage in nursing, hive maintenance and foraging, and long lived winter bees (diutinus bees) which remain within the hive and are essential for thermoregulation. Label free quantitative proteomic analysis...
ORGANISM(S): Apis mellifera (Honeybee) 
2022-11-21 | PXD030481 | Pride
Apis mellifera Proteomic comparison Workers 
ProteomicsProteomic comparison of summer and winter Apis mellifera workers shows reduced protein abundance in winter samples
Apis mellifera workers in temperate climates display two castes; short lived summer bees that engage in nursing, hive maintenance and foraging, and long lived winter bees (diutinus bees) which remain within the hive and are essential for thermoregulation. Label free quantitative proteomic analysis...
ORGANISM(S): Apis mellifera (Honeybee) 
2022-05-20 | PXD030483 | Pride
Apis mellifera Proteomic comparison Workers 
ProteomicsThe human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen Aspergillus fumigatus.
Aspergillus fumigatus contributes to invasive and allergic pulmonary disease in immunocompromised individuals. The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the pleiotropic cathelicidin antimicrobial peptide LL-37 and the aim of this work was to assess the effect o...
ORGANISM(S): Aspergillus fumigatus var. fumigatus 
2018-05-22 | PXD008143 | Pride
Growth Ll-37 Aspergillus Antimicrobial 
ProteomicsThe acute host – pathogen interactions between Aspergillus fumigatus and Galleria mellonella
Larvae of the greater wax moth Galleria mellonella are an ideal in vivo model to quickly and easily assess the virulence of a range of human pathogens, to comprehensively analyse the host – pathogen interactome and to reproducibly evaluate the in vivo toxicity and efficacy of anti-microbial agents. ...
ORGANISM(S): Galleria mellonella 
2018-06-21 | PXD008196 | Pride
Galleria aspergillus virulence infection mini-model 
ProteomicsExposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome inhibiting protein synthesis and reducing virulence
The antimicrobial properties of silver have been exploited for many centuries and continue to gain interest in the fight against antimicrobial drug resistance. The broad-spectrum activity and low toxicity of silver has led to its incorporation into a wide range of novel antimicrobial agents, includi...
ORGANISM(S): Candida parapsilosis CDC317 
2022-06-28 | PXD025693 | Pride
Antimicrobial Silver Proteomics Candida 
ProteomicsExposure of Aspergillus fumigatus to Klebsiella pneumoniae culture filtrate inhibits growth and stimulates gliotoxin production.
Aspergillus fumigatus is an opportunistic fungal pathogen of the lungs resulting in both chronic and acute infection. The fungus interacts with numerous bacteria that compose the microflora of the lung including Pseudomonas aeruginosa and Klebsiella pneumoniae, both common isolates from Cystic fibro...
ORGANISM(S): Aspergillus fumigatus Af293 
2023-03-11 | PXD037833 | Pride
Aspergillus Proteomics Gliotoxin Klebsiella Polymicrobial interaction 
ProteomicsProteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae
Mycetoma is a neglected chronic and granulomatous infection primarily associated with the fungal pathogen Madurella mycetomatis. Infection is characterised by the formation of fungal grains inside the infected tissue which commonly result in severe deformity and disability. Currently the biochemical...
ORGANISM(S): Galleria mellonella Madurella mycetomatis 
2020-03-19 | PXD013532 | Pride
Infection Immunity Grain Madurella  galleria In vivo screening Proteomics Mini-model 
ProteomicsProteomic characterisation of Aspergillus fumigatus – host interactions using the ex-vivo pig lung model (EVPL)
Aspergillus fumigatus is an environmental saprophyte and an opportunistic fungal pathogen of the human airway. A. fumigatus can cause a variety of chronic infections, typically in the context of pre-existing lung damage. Animal models of infection are costly and often cannot recapitulate phenotypes ...
ORGANISM(S): Sus scrofa scrofa Aspergillus fumigatus var. fumigatus 
2025-05-20 | PXD060389 | Pride
Aspergillus Infection Ex vivo Porcine Proteomics 
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